Objective: To investigate the clinical efficacy of Shenyan Kangfu tablet combined with standard hormone scheme in the treatment of nephrotic syndrom (NS) with syndrome of deficiency of both Qi and Yin and its influece on platelet count (PLT) and plasma level of pituitary adenylate cyclase-activating polypeptide (PACAP). Method: One hundred and fifty-two patients with NS were divided into treatment group (80 cases) and control group (72 cases) according to stratified random method. Both groups were given with supportive treatment and symptomatic treatment. The patients in control group were treated with prednisone at initial dose of 1 mg·kg-1 once a day

with maximum dose not more than 60 mg·d-1

orally for 8 to 12 weeks. Then the dose of prednisone was decreased by 10 percent every 2 weeks

and finally the dose was used with 10 mg·d-1 for 6 to 12 months. At the same time

symptomatic treatment was allocated. Patients in treatment group were added with Shenyan Kangfu tablet for 12 months

5 pills/time and tid. Urine protein quantitation for 24 hours

level of albumin (ALB)

total cholesterol (TC)

and triglyceride (TG) before and after treatment were measured in both groups. Liver function was monitored and incidence of adverse reactions in the treatment process was recorded. Scores of single symptoms in traditional Chinese medical (TCM) before and after treatment were compared for both groups. PLT and plasma PACAP levels were detected for both groups. Result: The total effective rate of treatment group was 97.5%

significantly higher than 79.17% in control group (P<0.01). After treatment

levels of urine protein quantitation for 24 hours

TC

and TG in treatment group were significantly lower than those in control group

and ALB level was significantly higher than that in control group (P<0.01). After treatment

the incidence of central obesity and overall incidence of adverse reactions were in treatment group were significantly lower than those in control group

(P<0.05). After treatment

scores of TCM single indexes in treatment group were significantly lower than those in control group

with statistically significant difference (P<0.01). After treatment

PLT in treatment group was significantly lower than that in control group

while plasma PACAP level was significantly higher than that in control group

with statistically significant difference (P<0.01). Conclusion: Shenyan Kangfu tablet combined with standard hormone scheme could remarkably improve therapeutic efficacy of NS with syndrome of deficiency of both Qi and Yin

reduce adverse reactions

and reduce PLT and increase plasma PACAP level.