Objective: The present study was designed to investigate the effects of Naoluo Xintong capsules on platelet aggregation and thrombus formation in rats with focal cerebral ischemia/reperfusion injury. Method: Male SD rats were randomly divided into sham operation group (n=10)

modeling group (n=60). Middle cerebral artery occlusion/reperfusion (MCAO/R) models were induced by the intraluminal suture method. The successfully modeled rats were randomly divided into model group

Aspirin group (0.010 g·kg-1)

Naoluo Xintong capsules high

middle and low dose groups (4.500

2.250

1.125 g·kg-1). Transmission electron microscope was used to observe the ultrastructure changes of hippocampal neurons. The levels of serum thromboxane B2(TXB2)

6-keto prostaglandin F1α(6-keto-PGF1α)

platelet aggregation rate and in vivo thrombus formation time were detected. Result: Compared with the sham operation group

pathological changes of the neurons in model group were severely damaged

TXB2 level in serum was significantly increased

6-keto-PGF1α level was significantly reduced

and platelet aggregation rates at 1

2

5 min and maximum aggregation rate in model group were significantly increased (P<0.05

P<0.01). Compared with the model group

pathological morphology of neurons in Naoluo Xintong capsules groups (1.125

2.250

4.500 g·kg-1) was significantly improved. After Naoluo Xintong capsules treatment

the serum TXB2 level was significantly decreased. In contrast

the level of serum 6-keto-PGF1α was increased. The platelet aggregation rate in Naoluo Xintong capsules low

middle and high dose groups in 1 min and 2 min was significantly lower than that in the model group

and the platelet aggregation rate in Naoluo Xintong capsules low and high dose groups and maximum aggregation rate in low and the middle dose groups in 5 min were significantly decreased. The thrombus formation time in Naoluo Xintong capsules low and middle dose groups was markedly prolonged (P<0.05

P<0.01). Conclusion: Naoluo Xintong capsules can inhibit the platelet aggregation and thrombus formation in focal cerebral ischemia/reperfusion injury models

with certain protection effect for ischemic cerebral vascular diseases.