Objective: To optimize formulation and preparation process of Peiyuan granules which will provide scientific references for clinical development of Peiyuan granules. Method: Single factor tests were performed to choose formulation and preparation process

with formability

hygroscopicity and fluidity as indexes.Moisture content

fluidity

bulk density and critical relative humidity of Peiyuan granules were inspected. Result: Optimum process conditions of Peiyuan granules were as follows:dry extract powder-dextrin-soluble starch (5:3:3)

wetting agent of 90% ethanol

wet granulation dried at 60℃ for 1 h.Yield

moisture content

angle of repose

bulk density and critical relative humidity were 95.78%

5.08%

30.73°

0.526 g·mL-1

70%. Conclusion: This formation process is reasonable and feasible.Moisture content

fluidity and bulk density of Peiyuan granules are up to requirements of the 2010 edition of Chinese Pharmacopoeia.