Estrogenic Effect of Combined Administration of Veratri Nigri Radix and Salviae Miltiorrhizae Radix et Rhizoma

CHEN Ting; LI Xin; QU Ya-kun; XU Ying; LIN Na

doi:10.13422/j.cnki.syfjx.2015220040

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Estrogenic Effect of Combined Administration of Veratri Nigri Radix and Salviae Miltiorrhizae Radix et Rhizoma

更新时间：2024-01-04

- Estrogenic Effect of Combined Administration of Veratri Nigri Radix and Salviae Miltiorrhizae Radix et Rhizoma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 22, Pages: 40-44(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015220040
  CLC： R285.5
- Published：2015
- 稿件说明：
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CHEN Ting, LI Xin, QU Ya-kun, et al. Estrogenic Effect of Combined Administration of Veratri Nigri Radix and Salviae Miltiorrhizae Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(22): 40-44.
DOI：

CHEN Ting, LI Xin, QU Ya-kun, et al. Estrogenic Effect of Combined Administration of Veratri Nigri Radix and Salviae Miltiorrhizae Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(22): 40-44. DOI： 10.13422/j.cnki.syfjx.2015220040.

摘要

目的:观察藜芦配伍丹参对未成熟小鼠雌激素样作用的影响

为中药十八反藜芦反丹参的配伍禁忌内涵提供实验依据。方法:取健康、出生21 d的昆明种雌性小鼠100只

随机分为10组

分别为正常组

丹参高、低剂量组(3.2

1.6 g·kg-1)

阳性药雌二醇(E2)组(0.1 g·kg-1)组

丹参高、低剂量+藜芦(0.045 g·kg-1)组

E2+藜芦组

丹参高、低剂量+雌激素受体拮抗剂(ICI)组(0.005 g·kg-1)

E2+ICI组

每组10只

给药7 d后分别观察小鼠子宫系数、血清中E2

黄体生成素(LH)

促卵泡生成素(FSH)的水平及子宫、阴道的病理学变化。结果:与正常组比较

丹参高、低剂量组均能使未成熟小鼠的子宫系数显著增加(P<0.01

P<0.05)

血清中E2含量明显升高(P<0.01)

LH(P<0.05)和FSH(P<0.01

P<0.05)的水平显著降低

还能明显促进靶器官子宫、阴道的生长发育

与E2作用相似略弱;丹参高、低剂量组配伍藜芦后

子宫系数明显降低(P<0.05

P<0.01)

血清中E2含量明显降低(P<0.01

P<0.05)

LH(P<0.01)和FSH(P<0.05

P<0.01)水平明显升高

子宫和阴道的促生长发育作用减弱

与配伍ICI的作用趋势一致。同时

E2配伍藜芦后

子宫系数显著降低(P<0.01)

血清中E2含量明显降低(P<0.01)

LH和FSH水平明显升高(P<0.01)

子宫和阴道的促生长发育作用减弱

其作用与配伍ICI组相似。结论:丹参具有雌激素样作用

藜芦具有雌激素受体拮抗剂样作用

藜芦配伍丹参后能够妨害丹参的雌激素样作用。

Abstract

Objective: To observe the estrogen-like effect of the combined administration of Veratri Nigri Radix and Salviae Miltiorrhizae Radix et Rhizoma(SMRR) using immature mice model

so as to provide a scientific basis for eighteen incompatible medicaments Veratri Nigri Radix and SMRR according to theories of traditional Chinese medicine. Method: Totally 10021-day-old healthy Kunming female mice were randomly divided into 10 groups:normal

estradiol valerate (E2

0.1 g·kg-1)

E2 plus estrogen receptor antagonist (ICI

0.005 g·kg-1)

E2 plus Veratri Nigri Radix (VN

0.045 g·kg-1)

SMRR (SM

1.6

3.2 g·kg-1)

SM plus ICI

SM plus VN for 7 days respectively

with 10 mice in each group. The estrogen-like effect was detected by observing uterus index

E2 in serum

LH and FSH levels and histomorphology changes in uterus and vagina. Result: Compared with normal group

SM groups showed significant increase in the uterus index (P<0.01

P<0.05) and decrease in the level of E2 (P<0.01)

the level of LH (P<0.05) and FSH (P<0.01

P<0.05)

and the growth and development of uterus and vagina in immature mice

with a similar effect to E2 (P<0.01). In SM plus VN group

uterus index decreased(P<0.05

P<0.01)

level of E2 notably decreased (P<0.01

P<0.05)

level of LH (P<0.01) and FSH (P<0.05

P<0.01) increased

and the growth and development of uterus and vagina decreased

with a similar trend to the SM plus ICI group. Meanwhile

in E2 plus VN group

uterus index decreased(P<0.01)

level of E2 notably decreased (P<0.01)

level of LH and FSH increased (P<0.01)

and the growth and development of uterus and vagina decreased

with a similar effect to SM plus ICI group. Conclusion: These findings rprove that SMRR exerts estrogenic effect

VN has the anti-estrogen effect and can antagonize the estrogenic efficacy of SMRR.

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Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

School of Pharmacy，Shandong Analysis and Test Center，Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province，Key Laboratory for Natural Active Pharmaceutical Constituents Research in Universities of Shandong Province， Qilu University of Technology（Shandong Academy of Sciences）

Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao，Academy of Chinese Medical Sciences，Henan University of Chinese Medicine

Institute of Traditional Chinese Medicine， Heilongjiang University of Chinese Medicine

Graduate School，Heilongjiang University of Chinese Medicine

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