Objective: To study the antipyretic

anti-inflammatory and analgesic effect of Xiaoer Qingwen Jiere granules. Method: Wistar rats and Japanese white rabbits were selected. Antipyretic effect was investigated by subcutaneous injection of yeast induced fever in rats models and endotoxin induced fever in rabbits models. KM mice were selected

and acetic acid writhing and hot plate stimulation method was used to observe the analgesic effect. ear swelling

capillary permeability and hind paw inflammation swelling in ICR mice and SD rats were observed for investigating the anti-inflammatory effect. Result: Administration of Xiaoer Qingwen Jiere granules at 3.92 g·kg-1 and 15.68 g·kg-1 for 3 h could significantly reduce the rabbit anal temperature difference (P<0.05

P<0.01)

and administration of 3.78-30.24 g·kg-1 for 4 h could significantly reduce rat rectal temperature (P<0.05

P<0.01)

administration of 43.68 g·kg-1 could significantly reduce the writhing times of mice (P<0.05)

and 10.92

21.84 g·kg-1 for 2 h could significantly improve pain threshold of mice (P<0.05). Administration of 5.46-43.68 g·kg-1 continuously for 3 days could significantly reduce xylene induced right ear swelling in mice (P<0.01)

7.56 g·kg-1 could significantly reduce foot swelling degree (P<0.05)

15.12 g·kg-1 for 0.5

2

4 h could significantly reduce foot swelling degree (P<0.05

P<0.01)

30.24 g·kg-1 for 0.5-4 h could significantly reduce foot swelling degree (P<0.05

P<0.01).At 43.68 g·kg-1

absorbance value of peritoneal washing liquid was significantly lower than that in model group (P<0.05). Conclusion: Xiaoer Qingwen Jiere granule has antipyretic

anti-inflammatory and antipyretic analgesic effects.