Objective: To observe the effect of extracts from Ginseng Radix et Rhizoma

Notoginseng Radix et Rhizoma and Chuanxiong Rhizoma (GNC)on immune organ function and behavior of aging rats. Method: Totally 100 SD (Sprague Dawley) rats were selected to raise for 18-19 months to establish the model of natural aging rats. According to the horizontal stratification of weight

the model aging rats were randomly divided into 5 groups:aging model group

traditional Chinese medicine low-dose

medium-dose

high-dose groups (2305.64

1152.82

576.41 mg·kg-1) and resveratrol group (50 mg·kg-1). And another group of 2 month old SD rats was set up as young group. After 3-month intervention

the total number of cell crossing and the total behavior distance of rats were recorded through open field test. Rat serum reactive oxygen species (ROS) content

thymus index and spleen index were detected. Result: Compared with young group rats

the total number of cell crossing decreased in aging model group (P<0.01)

the total action distance of natural aging rats decreased (P<0.05)

serum ROS content increased (P<0.01)

and thymus index and spleen index decreased (both P<0.01). Compared with the aging model group

the number of cell crossing and total action distance of all traditional Chinese medicine groups and resveratrol group increased (P<0.05). The serum content of ROS decreased (P<0.05). Traditional Chinese medicine high-dose group and resveratrol group showed increase in the thymus index and spleen index (P<0.01)

the traditional Chinese medicine medium-dose group showed increase in the rat thymus index (P<0.05). Conclusion: The extracts from GNC can improve the mental retardation state of natural aging rats and enhance their space exploration capacity

improve the function of immune organs and reduce the serum ROS content of aging rats.