Preparation and Quality Evaluation of Shortstalk Monkshood Root Total Alkaloids Microemulsion

WU Yu-mei; CHEN Xiao-lan; LIN Ya-ping; LIU Wen; TANG Hong-yan; DAI Ya-jie

doi:10.13422/j.cnki.syfjx.2015230007

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Preparation and Quality Evaluation of Shortstalk Monkshood Root Total Alkaloids Microemulsion

更新时间：2024-01-04

- Preparation and Quality Evaluation of Shortstalk Monkshood Root Total Alkaloids Microemulsion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 21, Issue 23, Pages: 7-11(2015)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2015230007
  CLC： R283.6
- Published：2015
- 稿件说明：
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WU Yu-mei, CHEN Xiao-lan, LIN Ya-ping, et al. Preparation and Quality Evaluation of Shortstalk Monkshood Root Total Alkaloids Microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(23): 7-11.
DOI：

WU Yu-mei, CHEN Xiao-lan, LIN Ya-ping, et al. Preparation and Quality Evaluation of Shortstalk Monkshood Root Total Alkaloids Microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(23): 7-11. DOI： 10.13422/j.cnki.syfjx.2015230007.

摘要

目的:制备质量稳定的雪上一枝蒿总生物碱微乳

为该制剂的深入研究与开发提供参考。方法:选用不同的油相、乳化剂及助乳化剂

采用伪三元相图法进行雪上一枝蒿总碱微乳的处方筛选与制备

考察该制剂的稳定性及理化性质。采用HPLC测定雪上一枝蒿甲素的含量

流动相乙腈-pH 7.3磷酸盐缓冲溶液(20:80)

检测波长199 nm。结果:雪上一枝蒿总生物碱微乳最佳配比为雪上一枝蒿总生物碱、肉豆蔻酸异丙酯、聚氧乙烯35蓖麻油、无水乙醇、水质量分数分别为2%

3.3%

19.8%

9.9%

65.0%。载药微乳澄清透明

呈圆球形

粒径均在10~100 nm。于4

25℃下放置6个月内质量稳定。雪上一枝蒿甲素的质量分数2.28 mg·g-1。结论:优化的雪上一枝蒿总生物碱微乳处方达到了预期的要求

为该制剂的后期研究提供实验基础。

Abstract

Objective: To prepare shortstalk monkshood root total alkaloids microemulsion. Method: Formulation of shortstalk monkshood root total alkaloids microemulsion was selected and prepared by pseudo-ternary phase diagram method with different oil phase

emulsifier and co-emulsifier

and preliminarily study its stability and physicochemical properties.HPLC was adopted to determine the content of bullatine A. Result: The best prescription was total alkaloids in Aconitum brachypodum of 2%

isopropyl myristate of 3.3%

polyoxylethylene castor oil ether 35 of 19.8%

absolute ethanol of 9.9%

water of 65.0%.The microemulsion was clear

transparent and spherical with particle size among 10-100 nm.Storage at 4℃ and 25℃ for six months is stable.The content of bullatine A was 2.28 mg·g-1. Conclusion: The optimized microemulsion formulation can achieve expected requirements.It can lay a foundation for further study of shortstalk monkshood root total alkaloids microemulsion.

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Related Institution

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

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