Objective: To establish HPLC method for simultaneous determination of hydroxysafflor yellow A and salvianolic acid B in Baidianfeng pills. Method: The determination was performed on a Welchrom C18 column with acetonitrile-0.1% phosphoric acid as the mobile phase in gradient elution mode at the flow rate of 1.0 mL·min-1. The detection wavelength was 280 nm. Result: Hydroxysafflor yellow A presented a good linearity in the concentration range of 4.91-36.86 mg·L-1 (r=0.9995). The average rate of recovery was 99.12% with RSD 0.9%. Salvianolic acid B presented a good linearity in the concentration range of 14.99-112.42 mg·L-1 (r=0.9997). The average rate of recovery was 98.79% with RSD of 1.0%. Conclusion: This method is simple

accurate and reproducible

and it can be used for quality control of Baidianfeng pills.