HAN Lei, MA Shi-jing, JIANG Sen, et al. Preparation and Characterization of Phloretin Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 10-13.
DOI:
HAN Lei, MA Shi-jing, JIANG Sen, et al. Preparation and Characterization of Phloretin Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 10-13. DOI: 10.13422/j.cnki.syfjx.2015240010.
Preparation and Characterization of Phloretin Solid Dispersions
Objective: To prepare phloretin solid dispersions by improving solubility of phloretin in water and characterize physical properties of this preparation for providing a reference for industrial promotion of phloretin. Method: Taking povidone K-30(PVP K-30) as carrier material
drug-loading rate and solubility as indexes
phloretin solid dispersions were prepared by solvent method.Physical properties characterization of phloretin solid dispersions were analyzed by DSC
XRD and FT-IR. Result: When the mass ratio of phloretin to PVP K-30 was 1:9
drug-loading rate of phloretin solid dispersions was 95.99%;solubility of phloretin was 0.42 g·L-1
compared with reference substance of phloretin
solubility improved 14 times.Analysis result of DSC and XRD showed phloretin probably dispersed in PVP K-30 in the form of molecues or amorphous state.FT-IR result showed phloretin and PVP K-30 maybe associated in the form of hydrogen bond. Conclusion: After being prepared to solid dispersion
solubility of phloretin can significantly improve.