YE Xi-de, XU Xiao-qiang, ZHANG Jian-kang, et al. Tissue Distribution of Auraptene in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 69-72.
DOI:
YE Xi-de, XU Xiao-qiang, ZHANG Jian-kang, et al. Tissue Distribution of Auraptene in Rats[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(24): 69-72. DOI: 10.13422/j.cnki.syfjx.2015240069.
Objective: To investigate tissue distribution of auraptene in rats. Method: Rat intragastric administration method was used.The content of auraptene in tissue sample was calculated after determining four time points with intragastric administration and taking tissue samples successively by establish a standard curve for drugs in various tissues.Meanwhile
two sample quality control(QC) sample with high
medium and low concentrations were done for judging reliability of results of this batch of samples.Data were analyzed by Analyst 1.6 software. Result: With gastric administration by 100 mg·kg-1
auraptene was rapidly distributed in different tissues including heart
liver
spleen
lung
kidney
stomach
small intestine and muscle after 30 min.The concentration of auraptene in small intestine significantly decreased by 120 min
while drug concentrations in fat and blood mainly increased.The concentration of drug for other issues beside brain by 6 h were dropped greatly and then drug concentration of all main issues decreased significantly at 8 h. Conclusion: Auraptene soft capsule can be rapidly distributed in main tissues of rats after gastric administration
drug concentration in gastrointestinal tract is always high
its concentrations in liver and lung are higher than other tissues.In addition
the concentration of auraptene in brain tissue remains at a high level
which may be related to active targeting of auraptene soft capsule on senile dementia.
Comparison of Pharmacokinetics and Tissue Distribution of Free Anthraquinones and Gallic Acid in Mice with Ulcerative Colitis Before and After Processing of Rhei Radix et Rhizoma Carbonisata
Material Basis and Its Distribution in vivo of Qili Qiangxin Capsules Analyzed by UPLC-Q-Orbitrap-MS
Effect of Borneol on Pharmacodynamics,Pharmacokinetics and Brain Tissue Distribution of Main Active Ingredients of Jiaotaiwan in Depression Model Rats
Distribution of Nardosinone and Its Metabolites in Rats Analyzed by UPLC-Q-Exactive Orbitrap MS/MS
Analysis of Chemical Components and Tissue Distribution of Lujiao Formula Based on UPLC-Q-Orbitrap-MS
Related Author
SUN Jing
QI Yunpeng
LI Siyuan
HU Yingbo
ZHONG Linying
CHEN Jianbo
DONG Ling
ZHANG Jianwei
Related Institution
School of Life Sciences,Beijing University of Chinese Medicine
Third Grade Laboratory of Traditional Chinese Medicine(TCM) Preparations,National Administration of TCM,Shuguang Hospital Affiliated to Shanghai University of TCM
Affiliated Hospital of Nanjing University of Chinese Medicine