Objective: To observe the clinical effect of Zidan Yinxie granules combined with narrow-band ultraviolet in treating psoriasis vulgaris and its influence to serous interleukin-17(IL-17)

interleukin-22(IL-22) and interleukin-23(IL-23). Method: One hundred and sixteen patients were randomly divided into control group(58 cases) and observation group(58 cases) by random number table. Patients in control group received narrow-band ultraviolet(NB-UVB). Based on the treatment of control group

patients in observation group added Zidan Yinxie granules

4 g/time

3 times/day. Courses of treatment in two groups were both 8 weeks. All the patient had a 3 mouths follow-up to record the relapse. Scores of skin injury area and psoriasis area and severity index(PASI) were graded before the treatment and at the first

second and third month after treatment. And recurrences were also recorded. Before and after treatment

scores of dermatology life quality index(DLQI) and itch degree for visual analogue scale(VAS) were graded. And levels of IL-17

IL-22 and IL-23 were detected. Result: After treatment

the PASI

DLQI and VAS scores in observation group were inferior to these in control group(P<0.05

P<0.01).The effective rate was 84.48% in control group

which was superior to that was 93.1% in observation group. There was no statistically significant difference in two groups. The recurrence rate was 40.74% in observation group

which was less than the data was 63.26% in control group(P<0.05) during 3 months follow-up period.The average recurrence time in observation group was more than that in control group(P<0.05). Levels of serum IL-17

IL-22

IL-23 in observation group were lower than these standards in control group after therapy(P<0.01). Conclusion: Zidan Yinxie granules combined with narrow-band ultraviolet can relieve skin injury and pruritus

improve quality of life

make disease to be stabilized and reduce recurrence rate

its mechanism of action may related to regulating helper T cell 17(TH17) factors.