Objective: To study the safety and efficacy of Shenqi Fuzheng injection(SFI) combined with navelbline and cisplatin(NP) chemotherapy in treating non-small cell lung cancer(NSCLC). Method: We searched Cochrane Library

Pubmed

Embase

CNKI

CBM

VIP and Wanfang Data through computer for data as at June 2015.All of randomized controlled trials(RCTs) of SFI combine with NP chmemotherapy were searched

and research literatures included in the RCTs were also traced. Two researchers independently conducted the strict quality evaluation and data extraction for the included studies and made a Meta-analysis by using RevMan 5.3 software. Result: Totally 10 RCTs involving 688 patients were included into the study. The Meta-analysis results showed that compared with the pure application of NP chemotherapy regimens

Shenqi Fuzheng injection combined with NP chemotherapy can significantly improve the patients quality of life[OR=3.23

95% CI(2.09

2.09)

P<0.00001]

but with no significant difference between the two groups in the short-term efficacy[OR=1.38

95% CI(0.99

0.99)

P=0.06)]. In terms of adverse reactions

Shenqi Fuzheng injection combined with NP chemotherapy can reduce bone marrow suppression caused by NP chemotherapy {white blood cells decline[OR=0.33

95% CI(0.23

0.23)

P<0.00001]

hemoglobin decline[OR=0.46

95%CI(0.30

0.30)

P=0.0003]

platelet decline[OR=0.45

95% CI(0.31

0.31)

P<0.00001]}

but with no significant differences in the digestive tract reactions[OR=0.60

95%CI(0.26

0.26)

P=0.24]

and phlebitis[OR=0.98

95%CI(0.57

0.57)

P=0.95]

neurotoxic[OR=0.78

95%CI(0.25

0.25)

P=0.67]

liver function damage[OR=0.73

95%CI(0.30

0.30)

P=0.50] and renal impairment[OR=1.48

95% CI(0.28

0.28)

P=0.64)]. Conclusion: Shenqi Fuzheng injection combined with NP chemotherapy in treating non-small cell lung cancer can effectively improve the quality of life

reduce severe bone marrow suppression caused by chemotherapy

but with no significant difference in the short-term efficacy

gastrointestinal adverse reactions

phlebitis

nerve toxicity

liver and kidney function damage from the simple NP chemotherapy. Therefore

more strict randomized

double-blind trials with a large sample size are required to further verify the efficacy and safety of Shenqi Fuzheng injection combined with NP chemotherapy in treating non-small cell lung cancer.