Objective: To study the safety and efficacy of modified Banxia Xiexin Tang in treating reflux esophagitis(RE). Method: We searched Pubmed

The Cochrane Library

Embase

CNKI

CBM

VIP and Wanfang Data through computer for data June 20

2015.All of Randomized Controlled Trials(RCTs) of modified Banxia Xiexin Tang in treating reflux esophagitis were searched

and research literatures included in the RCTs were also traced. Two researchers independently conducted the strict quality evaluation and data extraction for the included studies on the basis of the Cochrane system assessor handbook 5.1

and made a Meta-analysis by using RevMan 5.3 software. Result: Totally 12 RCTs involving 914 patients were included into the study. The Meta-analysis results showed that compared with the pure application of western medicine

modified Banxia Xiexin Tang in treating reflux esophagitis can significantly improve the comprehensive clinical efficacy[OR=3.41

95%CI(2.22

5.23)

P<0.00001]

improve the efficacy under gastroscope[OR=1.58

95%CI(1.04

2.41)

P=0.03] and reduce the recurrence rate[OR=0.23

95%CI(0.14

0.40)

P<0.00001]

with statistical significant differences. In the Adverse reactions

one study showed follow-up reports that the treatment group showed no obvious adverse reaction

whereas the control group showed 14 different degree of adverse reactions

including 4 cases of nausea

7 cases of headache

2 cases of abdominal pain

1 case of soreness of waist

but all of them were tolerant to the drug until the end of the treatment

and the above adverse reactions were relieved with the continuous medication.Sensitivity analysis results showed a stable efficacy evaluation

asymmetric 'Funnel Plot' analysis

with the potential publication bias. Conclusion: Banxia Xiexin Tang in treating reflux esophagitis shows a superior comprehensive clinical efficacy to conventional western medicine

without any severe adverse effect. Therefore

more multicenter

randomized

double-blind trials with a large sample size are required to further verifythe efficacy and safety of Banxia Xiexin Tang in treating reflux esophagitis.