Objective: To prepare Ershiwuwei Feibing pellets with high drug loading for improve compliance and absorption of this Tibeten medicine

and investigate its properties. Method: Extrusion-spheronization method was employed to prepare pellets.Taking content ratio of craw drug and microcrystalline cellulose

water content

extrusion velocity and rolling speed as factors

yield and spherical degree of pellets as indexes

central composite design-response surface methodology was used to optimize preparation process.Micromeritic properties and in vitro dissolution of this pellets were determined. Result: Optimum formulation was as following:medicine materials powder-microcrystalline cellulose(2.7:1)

water content of 34%

extrusion velocity of 14.7 Hz

rolling speed of 39.5 Hz and rolling time of 5 min.Cumulative release rate of hydroxysafflor yellow A was up to 80% in 60 min

cumulative release rate of alantolactone was four times as high as that of the commercial products. Conclusion: Extrusion-spheronization technique can prepare Ershiwuwei Feibing pellets with excellent quality

it has good roundness and high yield with impressive in vitro dissolution of two index components.