CHEN Xin, ZHU Hong-yu, LI Yang, et al. Development of Basic Formulation of Solid Preparations of Panacis Quinquefolii Radix Extract[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(1): 10-13.
DOI:
CHEN Xin, ZHU Hong-yu, LI Yang, et al. Development of Basic Formulation of Solid Preparations of Panacis Quinquefolii Radix Extract[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(1): 10-13. DOI: 10.13422/j.cnki.syfjx.2016010010.
Development of Basic Formulation of Solid Preparations of Panacis Quinquefolii Radix Extract
Objective: To investigate compatibility between Panacis Quinquefolii Radix extract and different pharmaceutical excipient
in order to provide a reference for basic formulation design of solid preparations of Panacis Quinquefolii Radix extract. Method: HPLC was employed to determine contents of ginsenoside Rg1
Re
Rb1
Rc
Rb2
Rb3
Rd with mobile phase of acetonitrile-water for gradient elution and detection wavelength at 203 nm.Taking appearance and total content of index components as indexes
single factor tests were used to investigate compatibility of extract and different pharmaceutical excipient. Result: Contents of ginsenosides decreased significantly under high humidity condition and appearance changed
in other conditions
these indexes relatively stable. Conclusion: Lactose
microcrystalline cellulose
sodium carboxymethyl starch sodium and magnesium stearate can be used as suitable material for solid preparation of Panacis Quinquefolii Radix extract.High humidity condition will affect stability of preparation of Panacis Quinquefolii Radix extract
so it should be kept closed in order to prevent moisture absorption.
Establishment of UPLC-PDA Fingerprint of Baoyuantang Substance Benchmark and Identification of Its Chemical Constituents
Effect of Sulfur Fumigation on Content of Chemical Constituents in Panacis Quinquefolii Radix and Preliminary Study on Its Identification Method
Effect of Acori Tatarinowii Rhizoma on Intestinal Absorption of Ginsenosides in Dingzhi Xiaowan
Application of Excipients for Oral Colon-targeting Drugs
Related Author
Peng LIU
A-qian CHANG
Guang-wei ZHU
Jiang XU
Qing-an LI
Hui HU
Huan-bo CHENG
Yang YU
Related Institution
Jing Brand Chizhengtang Pharmaceutical Co. Ltd.,Hubei Provincial Engineering Technology Research Center of Traditional Chinese Medicine (TCM) Formula Granule, Hubei Provincial Key Laboratory for Quality and Safety of TCM Health Food
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
Beijing University of Chinese Medicine
Adverse Drug Reaction Monitoring Center, Zhenjiang Institute for Food and Drug Control
School of Medicine, School of Pharmacy, Jiangsu University