Objective: To investigate the clinical effect of Yiqi Guben Tiaomian decoction in throat-oriented treatment of IgA nephropathy patients with Qi and Yin deficiency syndrome. Method: Seventy-nine patients with IgA nephropathy were randomly divided into treatment group(39 cases

Yiqi Guben Tiaomian decoction) and control group(40 cases

Guben Tongluo decoction)

with a two-month course of therapies. Result: ① Scores of throat in treatment group were significantly reduced(P<0.01)

while there was no significant improvement in control group

with significantly statistical difference(P<0.01). ②Red blood cell count of urine and 24 h urinary protein excretion were reduced in control group(P<0.05)

and significantly reduced in treatment group(P<0.01)

with significantly statistical difference between two groups(P<0.01).The total effective rate was 84.6% in treatment group and 57.5% in control group

with significantly statistical difference between two groups(P<0.01). ③The positive relationship between the scores of throat and red blood cell count of urine(P<0.01) as well as the level of 24 h urinary protein excretion(P<0.05) was found. Conclusion: Yiqi Guben Tiaomian decoction is effective to throat-oriented treatment of IgA nephropathy with Qi and Yin deficiency syndrome and improve the symptoms of IgA nephropathy by clearing heat and relieving sore-throat

which may provide new insight for the therapy of IgA nephropathy.