QIN Xue, YANG Jin-rong, JIN Mei-na, et al. Preparation Process and Quality Analysis of Jieyu Shuxin Granules[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 6-9.
DOI:
QIN Xue, YANG Jin-rong, JIN Mei-na, et al. Preparation Process and Quality Analysis of Jieyu Shuxin Granules[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 6-9. DOI: 10.13422/j.cnki.syfjx.2016020006.
Preparation Process and Quality Analysis of Jieyu Shuxin Granules
Objective:To optimize preparation process of Jieyu Shuxin granules and set up its quality standard. Method:According to characteristics of granules
wet granulation was employed
kinds and amounts of excipients in granules were optimized with indexes of solubility
clarity and powder ratio.With qualified rate of particle size as index
orthogonal test was adopted to optimize formulation process by taking ethanol concentration
amounts of dextrin and xylitol as factors.HPLC-ELSD was employed to determine contents of jujuboside A and B in this granules with acetonitrile-water (35:65)as mobile phase and column temperature at 35℃. Result:Xylitol had the best clarity with minimum powder ratio.Optimum recipe ratio was dry extract-xylitol-dextrin (0.5:15:7)
50% ethanol as a adhesive.Contents of jujuboside A and B in Jieyu Shuxin granules were 0.683
1.369 mg·g-1
respectively. Conclusion:These methods are proved to be reliable
sensitive and specific
which can be used in quality control of Jieyu Shuxin granules.
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