Optimization of Extraction Technology of Volatile Oil in Chuangui Huoxiang Granules and Its Pharmacodynamics Analysis

MENG Chao; YANG Jian-long; WANG Hai-yang; LI Fang-tong; WANG Kang-yu; LI Jian-nan

doi:10.13422/j.cnki.syfjx.2016020021

您当前的位置：

首页 >

文章列表页 >

Optimization of Extraction Technology of Volatile Oil in Chuangui Huoxiang Granules and Its Pharmacodynamics Analysis

更新时间：2024-01-04

- Optimization of Extraction Technology of Volatile Oil in Chuangui Huoxiang Granules and Its Pharmacodynamics Analysis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 2, Pages: 21-23(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016020021
  CLC： R283.6
- Published：2016
- 稿件说明：
移动端阅览
MENG Chao, YANG Jian-long, WANG Hai-yang, et al. Optimization of Extraction Technology of Volatile Oil in Chuangui Huoxiang Granules and Its Pharmacodynamics Analysis[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 21-23.
DOI：

MENG Chao, YANG Jian-long, WANG Hai-yang, et al. Optimization of Extraction Technology of Volatile Oil in Chuangui Huoxiang Granules and Its Pharmacodynamics Analysis[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 21-23. DOI： 10.13422/j.cnki.syfjx.2016020021.

摘要

目的:优选川归藿香颗粒中挥发油的提取工艺

并考察该制剂的药效。方法:以挥发油提取率为评价指标

采用正交试验考察萃取时间、压力、温度对川归藿香颗粒中挥发油提取工艺的影响

通过热板镇痛试验、扭体试验和耳肿胀试验考察颗粒剂的消炎镇痛作用。结果:最佳提取工艺条件为萃取压力25 MPa

萃取温度50℃

萃取时间1.5 h;挥发油提取率38.3 mg·g-1。按新、旧工艺制备的川归藿香颗粒具有镇痛、抗炎作用

且前者的药效强于后者。结论:优选的提取工艺设计合理、稳定可行

适合于工业化生产

制备的川归藿香颗粒能延长小鼠痛阈值

减少小鼠扭体次数

抑制小鼠耳肿胀度。

Abstract

Objective:To optimize extraction technology of volatile oil in Chuangui Huoxiang granules and investigate its pharmacodynamics. Method:Taking yield of volatile oil as index

orthogonal test was adopted to optimize extraction technology of volatile components with extraction time

pressure and temperature as factors.Analgesic and anti-inflammatory effects of this granules was studied by hot plate analgesia experiment

writhing test and ear swelling experiment. Result:Optimum extraction conditions were as follows:extraction pressure of 25 MPa

temperature at 50℃ and lasting for 1.5 h;yield of volatile oil was 3.83 mg·g-1.Chuangui Huoxiang granules had analgesic and anti-inflammatory effects which prepared by the new process or the old process

and efficacy of the former was stronger than the latter. Conclusion:This optimized extraction process is reasonable

stable and suitable for industrial production of Chuangui Huoxiang granules

this granules can prolong pain threshold of mice

decrease writhing response of mice and inhibit ear swelling degree in mice.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

GC-MS Analysis of Effect of Different Processing Conditions on Irritation of Magnoliae Officinalis Cortex

Volatile Oil of Linderae Radix Induces Apoptosis and Autophagy of Gastric Cancer AGS Cells via AMPK/mTOR Signaling Pathway

Analysis of Quality Value Transmitting of Volatile Oil in Bran-processed Atractylodes lancea and Its Standard Decoction with Different Physicochemical Forms

Comparison of Character，Turgidity and Chemical Composition of Prunellae Spica Seeds，Chia Seeds and Basil Seeds

Effect of Light and Temperature on Photosynthetic Fluorescence Parameters and Volatile Oil Content of Atractylodes lancea

Related Author

CAI Pingjun

QIANG Mengqin

XIA Yangmiao

JIA Yaoxia

MENG Xiangqi

LEI Jinjie

LIU Fang

YU Lingying

Related Institution

State Key Laboratory of Southwestern Chinese Medicine Resources， Chengdu University of Traditional Chinese Medicine

Basic Medical College， Heilongjiang University of Chinese Medicine

College of Pharmacy， Heilongjiang University of Chinese Medicine

Hubei Research Center of Chinese Materia Medica Processing Engineering and Technology， School of Pharmacy，Hubei University of Chinese Medicine

National Engineering Laboratory for Quality Control Technology of Chinese Materia Medica， Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰