Optimization of Clarification Process for Yinma Oral Liquid by Overall Desirability

ZHANG Lin; LI Yuan-bo; ZHANG Ai-jun

doi:10.13422/j.cnki.syfjx.2016020024

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Optimization of Clarification Process for Yinma Oral Liquid by Overall Desirability

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- Optimization of Clarification Process for Yinma Oral Liquid by Overall Desirability
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 2, Pages: 24-27(2016)
- 作者机构：
- 作者简介：
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- DOI：10.13422/j.cnki.syfjx.2016020024
  CLC： R286
- Published：2016
- 稿件说明：
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ZHANG Lin, LI Yuan-bo, ZHANG Ai-jun. Optimization of Clarification Process for Yinma Oral Liquid by Overall Desirability[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 24-27.
DOI：

ZHANG Lin, LI Yuan-bo, ZHANG Ai-jun. Optimization of Clarification Process for Yinma Oral Liquid by Overall Desirability[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 24-27. DOI： 10.13422/j.cnki.syfjx.2016020024.

摘要

目的:优选银马口服液的澄清工艺

为该制剂的工业化生产提供参考。方法:建立浊度对数方程测定法

以绿原酸含量、固含量、浊度的总评"归一值"为评价指标

采用正交试验考察壳聚糖用量、澄清温度、澄清时间及pH对银马口服液澄清工艺的影响

通过测定粒径及Zeta电位进行稳定性分析。结果:最佳澄清工艺条件为调节pH 4.5

壳聚糖用量0.1%

搅拌时间10 min

40℃水浴加热2 h

4℃冷藏静置12 h;绿原酸质量浓度0.0855 g·L-1

固含量6.60 g·L-1

浊度9.967 NTU。80.9%的微粒平均粒径1.170μm

98.2%的微粒平均Zeta电位-0.778 mV。结论:优选的澄清工艺稳定可行

澄清效果好。澄清后银马口服液体系稳定。

Abstract

Objective:To optimize clarification technology of Yinma oral liquid. Method:A logarithmic equation for turbidity determination was established.Orthogonal test was adopted to investigate effects of chitosan dosage

pH value

clarification temperature and time on overall desirability of the content of chlorogenic acid

solid content and turbidity.Particle size and Zeta potential was used for stability analysis. Result:Optimal clarification technology conditions was as follows:chitosan dosage of 0.1%

stirring time of 10 min

pH 4.5

heated for 2 h at 40℃ and refrigerated 12 h at 4℃.The content of chlorogenic acid was 0.0855 g·L-1

solid content was 6.60 g·L-1 and turbidity was 9.967 NTU.Average particle size of 80.9% particles was 1.170μm and average Zeta potential of 98.2% particles was -0.778 mV. Conclusion:This clarification process is stable and feasible with a good clarifying effect

and Yinma oral liquid system is stable after clarification.

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