LI Wei, LUO Xian-qin, ZHOU Wen-jie, et al. Optimization of Extraction Process of Xiaoer Feike Oral Liquid by Combining with Orthogonal Design and Pharmacodynamic Test[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 28-32.
DOI:
LI Wei, LUO Xian-qin, ZHOU Wen-jie, et al. Optimization of Extraction Process of Xiaoer Feike Oral Liquid by Combining with Orthogonal Design and Pharmacodynamic Test[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 28-32. DOI: 10.13422/j.cnki.syfjx.2016020028.
Optimization of Extraction Process of Xiaoer Feike Oral Liquid by Combining with Orthogonal Design and Pharmacodynamic Test
Objective:To optimize extraction process of Xiaoer Feike oral liquid and provide a reference for industrial production of this preparation. Method:Developing the antitussive
antiasthmatic and expectorant experiments
the best extraction method was optimized.Single factor tests was adopted to investigate effects of the amount of water
soaking time and extraction time on extraction process of volatile oil.With contents of ginsenoside Rb1 and hesperidin
dry extract yield as comprehensive evaluation index
orthogonal design was adopted to predict ethanol process conditions by taking ethanol volume
extraction time and times as factors. Result:Optimum extraction process of volatile oil were as follows:adding 8 folds of water
extracting for 8 h after being soaked 0.5 h;yield of volatile oil was 0.81 mL.The best conditions for ethanol extraction process were extracting thrice with 8 times of 75% ethanol
2 hours for per time.Extracting amounts of ginsenoside Rb1 and hesperidin were 1.59
2.84 mg·g-1
dry extract rate was 19.53%. Conclusion:These optimized technologies are stable and reliable for industrial production of Xiaoer Feike oral liquid.
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