Selecting Active Constituents of Siraitiae Fructus on Inhibition of  Bacterial Biofilms

WANG Hai-yang; WANG Tao; LI Hong-yue; XU Duo-duo

doi:10.13422/j.cnki.syfjx.2016020051

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Selecting Active Constituents of Siraitiae Fructus on Inhibition of Bacterial Biofilms

更新时间：2024-01-04

- Selecting Active Constituents of Siraitiae Fructus on Inhibition of Bacterial Biofilms
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 2, Pages: 51-54(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016020051
  CLC： R378
- Published：2016
- 稿件说明：
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WANG Hai-yang, WANG Tao, LI Hong-yue, et al. Selecting Active Constituents of Siraitiae Fructus on Inhibition of Bacterial Biofilms[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 51-54.
DOI：

WANG Hai-yang, WANG Tao, LI Hong-yue, et al. Selecting Active Constituents of Siraitiae Fructus on Inhibition of Bacterial Biofilms[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 51-54. DOI： 10.13422/j.cnki.syfjx.2016020051.

摘要

目的:研究罗汉果抑制大肠埃希菌生物膜(BBF)有效部位的化学成分及单体活性。方法:以大肠埃希菌BBF为模型对罗汉果的有效部位进行筛选

采用柱色谱等方法分离其有效部位中的化学成分

鉴定其结构

并研究它们对大肠埃希菌生物膜的影响。结果:95%乙醇洗脱部位为有效部位

并从中分离得到3个化合物

分别为十六烷酸(1)

环-(亮氨酸-异亮氨酸)(2)

谷甾醇-3-O-葡萄糖(3)。在质量浓度为1000 mg·L-1时

化合物1

3对大肠埃希菌生物膜的抑制率分别为51.47%

76.34%

67.01%。结论:化合物3首次从罗汉果中分离得到。

Abstract

Objective:To study the effective fraction and compounds from Siraitiae Fructus on inhibition of Escherichia coli biofilms. Method:The E. coli bacterial biofilms (BBF) was used as the model to screen the effective fraction of Siraitiae Fructus. The chemical compounds were isolated from effective fraction by column chromatography to identify their structures and study their effect on E. coli bacterial biofilms. Result:95% ethanol elution fraction was the effective fraction

and 3 compounds were obtained from it

including palmitic acid(1)

ring-(leucine-isoleucine acid)(2) and daucostero(3) respectively. Under the concentration of 1000 mg·L-1

the inhibition rates of compound 1

3 were 51.47%

76.34% and 67.01% on E. coli bacterial biofilms. Conclusion:Compound 3 is isolated from Siraitiae Fructus for the first time.

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Related Author

GAO Qi-pin

HE Min

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XU Duo-duo

ZHU Xiao-yun

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Related Institution

Guangxi University of Chinese Medicine

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