Objective:To investigate the effect of Qibai Pingfei (QBPF) capsule on chronic obstructive pulmonary disease (COPD) rats induced by lipopolysaccharides(LPS) and cigarette smoke

in order to determine its mechanism. Method:Normal rats of control group were bred for 4 weeks in normal circumstance before test and instilled intratracheally with normal saline once at day 1 and day 14.Rats of COPD group were exposed to cigarette smoke 2 h·d-1 for 4 weeks and intratracheally instilled with 200μg LPS once at day 1 and day 14.All COPD rats were divided randomly into five groups. Each group was orally administrated with QBPF granules 4.4

2.2

1.1 g·kg-1 and aminophylline 0.054 g·kg-1 respectively

while model group was administrated with solvent. After 4 weeks

lung function was recorded after administration

level of serum interleukin-1(IL-1β)

tumor necrosis factor-α (TNF-α)

interleukin-6(IL-6)

interferon-γ (IFN-γ) and lung tissue morphology were observed. Result:Compared with normal group

lung function indexes such as forced vital capacity (FVC)

forced expiratory volume in 0.3 second (FEV 0.3)

FEV 0.3/FVC

peak expiratory flow (PEF) decreased significantly(P<0.01);serum levels of IL-1β

and IL-6

IFN-γ

TNF-α significantly increased (P<0.01). Compared with model group

lung function indexes such as FVC

FEV 0.3

FEV 0.3/FVC

PEF rose significantly in the middle and high dose of QBPF group and aminophylline group (P<0.05

P<0.01). Compared with model group

QBPF granules group showed significant decrease in Serum levels of IL-1β

and IL-6

IFN-γ

TNF-α but increasein level of IL-10(P<0.05

P<0.01). Conclusion:QBPF granules can improve lung function

reduce the pathological changes of lung tissue. Its inflammatory reduction factors may be an important mechanism for treatment of chronic obstructive pulmonary disease.