Objective:To investigate the effect of Rubi Fructus's different extract parts on the memory disorders induced by scopolamine

Sodium nitrite and 40% Ethanol in rats

explore the effective extract parts of Rubi Fructus for the 3 memory disorder models

and provide the experimental evidence for research of mechanism of Rubi Fructus in improving the memory ability. Method:Intragastric 130 Kunming mice were randomly divided into 13 groups

n=10 in each group

including blank group

model group

positive group

Rubi Fructus whole prescription high dose group and low dose group

chloroform extract high dose group and low dose group

n-butyl alcohol extract high dose group and low dose group

ethyl acetate extract high dose group and low dose group

aqueous extract high dose group and low dose group. Administration groups respectively received ig high dose and low dose (24

12 g·kg-1) Rubi Fructus whole prescription

chloroform extract

n-butyl alcohol extract

ethyl acetate extract

and aqueous extract. The positive group received ginkgo leaves preparation 7.6 mg·kg-1. The blank group and the model group received same-volume-gavage of saline

continuous for 12 days. After 7 days

all mice except those in the blank group were intraperitoneally injected with corresponding 1 mg·kg-1 dose 30 min before test for the scopolamine-induced models

intraperitoneally injected with corresponding 120 mg·kg-1 after training for the sodium nitrite-induced models

and received intragastric administration of 0.1 mL·kg-1 30 min before test for 40% ethanol-induced models

to explore the navigation ability and space exploration ability in the Morris water maze. Result:Compared with the normal group

escape latency of three memory disorders were significantly prolonged

and the number of times for passing the platform was significantly reduced (P<0.05). Compared with the model group

Rubi Fructus whole prescription

chloroform extract

ethyl acetate extract

n-butanol extract

and water extract can shorten the escape latency of three memory disorders and enhance the number of times for passing the platform (P<0.05). Conclusion:Rubi Fructus's water extract high dose group has the best effect for improving the memory disorders induced by scopolamine and sodium nitrite. Rubi Fructus whole prescription high dose group has the best effect for improving memory disorders induced by 40% ethanol in mice.