Objective:To study effects of Zishen Qinggan formulaon on blood glucose

glycosylated hemoglobinAlc (HbAlc)

C-peptide (C-P)

glucagon-like peptide (GLP-1) and α-glucosidase activity in Goto-Kakizaki (GK) rats. Method:Rats with fasting blood glucose (FBG)>11.1 mmol·L-1were selected and randomly divided into the following groups:diabetic model group

Zishen Qinggan formula low dose group (ig

300 mg·kg-1·d-1)

middle dose group (ig

600 mg·kg-1·d-1)

and high dose group (ig

1200 mg·kg-1·d-1)

and metformin group (ig

85 mg·kg-1·d-1). After 28 d of continuous medication

fasting blood glucose (FBG) was detected and oral glucose tolerance test (OGTT) was done

then HbAlc

C-P

GLP-1 levels and α-glucosidase activity were detected. Result:Compared with the normal group

FBG and HbAlc levels in model group were significantly higher (P<0.01). Compared with the model group

FBG

HbAlc levels and the blood glucose level after 120 min of glucose tolerance were significantly reduced in Zishen Qinggan formula groups (P<0.05

P<0.01)

levels of C-P

and GLP-1 were significantly increased (P<0.05

P<0.01)

insulin resistance index was reduced (P<0.05)

and α-glucosidase activity was inhibited. Conclusion:Zishen Qinggan formula can effectively reduce blood glucose and improve insulin resistance in GK rats

and the action mechanism may be associated with increasing GLP-1 content and inhibiting α-glucosidase activity.