Meta-analysis of Efficacy of Traditional Chinese Medicine Dialectical Treatment Combination with Chemotherapy in Advance Non-small Cell Lung Cancer

DAI Yun-feng; GUO Zhen-lang; CHENG Jing; DENG Lu-ming; SU Zhen-ning; LUO Xiao-mu

doi:10.13422/j.cnki.syfjx.2016020180

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Meta-analysis of Efficacy of Traditional Chinese Medicine Dialectical Treatment Combination with Chemotherapy in Advance Non-small Cell Lung Cancer

更新时间：2024-01-04

- Meta-analysis of Efficacy of Traditional Chinese Medicine Dialectical Treatment Combination with Chemotherapy in Advance Non-small Cell Lung Cancer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 2, Pages: 180-185(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016020180
  CLC： R734.2
- Published：2016
- 稿件说明：
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DAI Yun-feng, GUO Zhen-lang, CHENG Jing, et al. Meta-analysis of Efficacy of Traditional Chinese Medicine Dialectical Treatment Combination with Chemotherapy in Advance Non-small Cell Lung Cancer[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 180-185.
DOI：

DAI Yun-feng, GUO Zhen-lang, CHENG Jing, et al. Meta-analysis of Efficacy of Traditional Chinese Medicine Dialectical Treatment Combination with Chemotherapy in Advance Non-small Cell Lung Cancer[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 180-185. DOI： 10.13422/j.cnki.syfjx.2016020180.

摘要

目的:系统评价中医辨证论治联合化疗方案治疗晚期非小细胞肺癌(non-small cell lung cancer

NSCLC)的临床效果以及安全性。方法:计算机检索The Cochrane Library

Pubmed

Embase

中国科技期刊全文数据库(VIP)

万方数据库

中国期刊全文数据库(CNKI)

中国生物医学文献数据库(CBM)等

检索时间限定为建库至2015年7月5日

检索所有中医辨证论治联合化疗方案治疗晚期非小细胞肺癌的随机对照试验(randomized controlled trials

RCTs)

并追索纳入研究的参考文献。由两位评价者独立对纳入研究的质量进行严格评价和资料提取后

采用RevMan 5.3软件进行Meta分析。结果:最终纳入12项RCT

共1341例患者。Meta分析结果显示:与单纯化疗相比

中医辨证论治联合化疗方案可有效提高临床近期疗效[OR=1.58

95%CI(1.03

2.42)

P=0.03]

改善患者生存质量[OR=4.38

95%CI(3.17

6.05)

P<0.00001]。不良反应方面

中医辨证论治联合化疗方案能减少化疗引起的骨髓抑制:白细胞下降[OR=0.21

95%CI(0.10

0.44)

P<0.0001]

血红蛋白下降[OR=0.29

95%CI(0.13

0.68)

P=0.004]

血小板下降[OR=0.26

95%CI(0.10

0.69)

P=0.007]

减少消化道不良反应[OR=0.23

95%CI(0.09

0.63)

P=0.004]

但在减少肝功能损害[OR=0.37

95%CI(0.08

1.66)

P=0.19]

肾功能损害[OR=0.51

95%CI(0.23

1.14)

P=0.10]方面两组差异均无统计学意义。结论:中医辨证论治联合化疗方案治疗晚期非小细胞肺癌能有效提高临床近期疗效和改善患者生存质量

减少化疗引起的严重骨髓抑制和消化道不良反应

但在减少肝肾功能损害方面和单纯使用化疗方案相比无显著性差异。鉴于本研究纳入RCTs数量和质量有限

中医辨证论治联合化疗方案治疗晚期非小细胞肺癌的临床疗效以及安全性仍需要严格的、大样本的随机双盲试验加以验证。

Abstract

Objective:To study the safety and efficacy of traditional Chinese medicine(TCM) dialectical treatment combination with chemotherapy in advance non-small cell lung cancer(NSCLC). Method:We searched The Cochrane Library

Pubmed

Embase

VIP

Wangfang Data

CNKI

CBM

from database inception to July5

2015.Randomized controlled trials (RCTs) of TCM dialectical treatment combination with chemotherapy in advance non-small cell lung cancer in any language were included

and recover into research references. Two researchers extracted data and assessed the literature quality separatedly

and made a Meta analysis RevMan 5.3 software. Result:The 12 RCTs involving 1341 patients entered the inclusion criteria. The Meta-analysis results showed that compared with the pure application of chemotherapy regimens

TCM dialectical treatment combination with chemotherapy can significantly improve the patients quality of life[OR=1.58

95%CI(1.03

2.42)

P=0.03]

curative effect in the near future[OR=4.38

95%CI(3.17

6.05)

P<0.00001]. Adverse reactions

TCM dialectical treatment combination with chemotherapy can reduce bone marrow suppression caused by chemotherapy (white blood cells decline[OR=0.21

95%CI(0.10

0.44)

P<0.0001]

hemoglobin decline[OR=0.29

95%CI(0.13

0.68)

P=0.004]

platelet decline[OR=0.26

95%CI(0.10

0.69)

P=0.007]

digestive tract reactions[OR=0.23

95%CI(0.09

0.63)

P=0.004]

but in the liver function damage[OR=0.37

95%CI(0.08

1.66)

P=0.19]

renal impairment[OR=0.51

95%CI(0.23

1.14)

P=0.10] were no significant differences. Conclusion:The current results indicates that TCM dialectical treatment combination with chemotherapy in advance non-small cell lung cancer can effectively improve the quality of survival

near future curative effect

reduce severe bone marrow suppression caused by chemotherapy

and gastrointestinal adverse reactions

but liver and kidney function damage and simple scheme there was no significant difference compared with chemotherapy. However

the efficacy and safety of TCM dialectical treatment combination with chemotherapy in advance non-small cell lung cancer still need more strict

large sample

randomized

double-blind trials to verify.

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Related Institution

Qingpu Branch, Zhongshan Hospital Affiliated to Fudan University

College of Integrated Chinese and Western Medicine， Liaoning University of Traditional Chinese Medicine

College of Integrated Traditional Chinese and Western Medicine， Liaoning University of Traditional Chinese Medicine

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Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province and Education Ministry of P.R. China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease，Henan University of Chinese Medicine

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