Meta-analysis of Efficacy and Safety of Yimucao Injection Combined with Oxytocin in Preventing Postpartum Hemorrhage During Cesarean Section

ZENG Lin-miao; ZHOU Xin-wei; YU Xiao-lian; YANG Li; CHEN Ying; PENG Qing-mei

doi:10.13422/j.cnki.syfjx.2016020200

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Meta-analysis of Efficacy and Safety of Yimucao Injection Combined with Oxytocin in Preventing Postpartum Hemorrhage During Cesarean Section

更新时间：2024-01-04

- Meta-analysis of Efficacy and Safety of Yimucao Injection Combined with Oxytocin in Preventing Postpartum Hemorrhage During Cesarean Section
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 2, Pages: 200-206(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016020200
  CLC： R714.461
- Published：2016
- 稿件说明：
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ZENG Lin-miao, ZHOU Xin-wei, YU Xiao-lian, et al. Meta-analysis of Efficacy and Safety of Yimucao Injection Combined with Oxytocin in Preventing Postpartum Hemorrhage During Cesarean Section[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 200-206.
DOI：

ZENG Lin-miao, ZHOU Xin-wei, YU Xiao-lian, et al. Meta-analysis of Efficacy and Safety of Yimucao Injection Combined with Oxytocin in Preventing Postpartum Hemorrhage During Cesarean Section[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(2): 200-206. DOI： 10.13422/j.cnki.syfjx.2016020200.

摘要

目的:评价益母草注射液联合缩宫素预防剖宫产术后产后出血的有效性及安全性。方法:计算机检索PubMed

EMbase

Cochrane图书馆

CNKI

VIP和万方数据库

检索时间均从建库至2014年9月。纳入益母草注射液联合缩宫素预防剖宫产术后产后出血的随机对照试验

并观察益母草注射液联合缩宫素预防剖宫产术后产后出血的产后出血量

产后出血发生率及不良反应发生率。按Cochrane系统评价方法

评价纳入研究的方法学质量并提取有效数据用RevMan 5.1软件进行Meta分析。结果:最终纳入25个试验

共纳入5709例患者。Meta分析结果显示:在术中出血量[MD=-44.96

95%CI(-64.15

-25.76)

P<0.00001]方面的差异有显著性;在术后2 h出血量[MD=-38.25

95%CI(-51.59

-24.90)

P<0.00001]方面的差异有显著性;在术后24 h出血量[MD=-49.26

95%CI(-65.66

-32.85)

P<0.00001]方面的差异有显著性;在产后出血发生率[OR=0.33

95%CI(0.25

0.43)

P<0.00001]方面的差异有显著性。两组间术后药物不良反应方面差异无显著性[OR=0.78

95%CI(0.41

1.47)

P=0.44]。结论:本研究结果提示

益母草注射液联合缩宫素预防剖宫产术后产后出血的产后出血量

产后出血发生率方面均优于对照组

且并不增加药物不良反应。益母草注射液联合缩宫素更适合用于防治剖宫产术后产后出血的发生。然而

受纳入研究数量及质量限制

本系统评价结果尚需更多高质量、大样本、多中心随机对照试验验证。

Abstract

Objective:To evaluate the effectiveness and safety of Yimucao injection combined with oxytocin in preventing postpartum hemorrhage during cesarean section. Method:Search was conducted in the following databases:PubMed

EMbase

Cochrane Library

CNKI

VIP and WanFang Data during the period from the established time to September 2014.Randomized controlled trial (RCT) of Yimucao injection combined with oxytocin in preventing postpartum hemorrhage during cesarean section were included

and its adverse drug reaction

postpartum bleeding and postpartum hemorrhage rate were observed. The quality of included studies was assessed according to Cochrane Methods 5.1 for systematic review

and Meta-analysis was conducted using RevMan 5.1 software. Result:A total of 25 studies involving 5709 patients were included. The Meta-analysis results indicated significant difference in intra-operative bleeding volume between Yimucao injection combined with oxytocin group and control group[MD=-44.96

95%CI(-64.15

-25.76)

P<0.00001];showed significant difference in 2 hours postoperative bleeding between the two groups[MD=-38.25

95%CI(-51.59

-24.90)

P<0.00001];showed significant difference in 24 hours postoperative bleeding between the two groups[MD=-49.26

95%CI(-65.66

-32.85)

P<0.00001]. The Meta-analysis showed a significant reduction in the risk of postpartum hemorrhage rates between two groups[OR=0.33

95%CI (0.25

0.43)

P<0.00001]. Side effect rates showed no significant difference between two groups[OR=0.78

95%CI(0.41

1.47)

P=0.44]. Conclusion:Compared with control group

Yimucao injection combined with oxytocin in preventing postpartum hemorrhage during cesarean section can significantly reduce postpartum bleeding and postpartum hemorrhage rate

without increasing the side effects for patients. We conclude that Yimucao injection combined with oxytocin is more appropriate for preventing postpartum hemorrhage during cesarean section. However

due to the limitation of both quantity and quality of included studies

this conclusion should be further confirmed with more high quality and large multicenter randomized controlled clinical trials.

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