GUAN Zhi-yu, WU Wen-ting, LIU Ya-li, et al. Optimization of Extraction Process and Pharmaceutical Formulation of Wuwei Jinse Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(3): 9-12.
DOI:
GUAN Zhi-yu, WU Wen-ting, LIU Ya-li, et al. Optimization of Extraction Process and Pharmaceutical Formulation of Wuwei Jinse Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(3): 9-12. DOI: 10.13422/j.cnki.syfjx.2016030009.
Optimization of Extraction Process and Pharmaceutical Formulation of Wuwei Jinse Dispersible Tablets
Objective: To optimize extraction process and pharmaceutical formulation of Wuwei Jinse dispersible tablets. Method: Taking composite score of contents of total polyphenols and gallic acid
dry extract rate as index
orthogonal test was adopted to investigate influence of extraction time
extraction times
the amount of water on water extraction process.With appearance
hardness and dispersion uniformity time as indexes
molding process of dispersible tablets was optimized by single factor tests. Result: Optimum extraction process consisted of adding 10-fold of waters
extracting 3 times
90 min for each time.Yield of total polyphenols was 6.29%
the content of gallic acid was 398.37 mg
dry extract rate was 24.28%.This dispersible tablets were made up of amylum pregelatinisatum
microcrystalline cellulose
croscarmellose sodium and micropowder silica gel
and it can be disintegrated completely and dispersed uniformly within 130 s. Conclusion: Optimized extracting process and pharmaceutical formulation are feasible and stable for industrial production of Wuwei Jinse dispersible tablets.
Determination of Total Polyphenols from Fruit in Guizhou and Investigation Its Drying Methods
Optimization of Purification Technology for Total Polyphenols from Juglandis Semen Kernel Pellicles by Macroporous Resin
Comparison of Pharmacokinetics and Tissue Distribution of Free Anthraquinones and Gallic Acid in Mice with Ulcerative Colitis Before and After Processing of Rhei Radix et Rhizoma Carbonisata
Gallic Acid Ameliorates Exercise-induced Muscle Damage in Mice by Regulating p53/SLC7A11/GPX4 Pathway
Analysis on Quality Attribute of Substance Benchmarks of Shentong Zhuyutang Based on Supramolecular "Imprinting Template" Theory
Related Author
LIU Dan
JIANG Fan
DING Xiao-yan
CAI Xiao-jing
ZHANG Chun-mei
CHEN Chao-yin
ZHAO Sheng-lan
XIE Ding-qi
Related Institution
School of Life Sciences,Beijing University of Chinese Medicine
The First Clinical Medical College,Nanjing University of Chinese Medicine
Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Province Hospital of Chinese Medicine
School of Pharmacy,Hunan Key Laboratory of Druggability and Preparation Modification of Traditional Chinese Medicine(TCM),Laboratory of Supramolecular Mechanism and Mathematic-physics Characterization for Chinese Materia Medica,Property and Pharmacodaynamic Key Laboratory of TCM,National Administration of TCM,Hunan University of Chinese Medicine
State Key Laboratory of Quality Evaluation of TCM,National Administration of TCM, Sichuan Academy of Chinese Medical Sciences