Objective: To establish the fingerprints of the dry extracts of Ficus Herba and Keteling capsules by HPLC and to identify their main compositions by LC-Q-TOF-MS. Method: HPLC was used to establish the fingerprints of dry extracts of Ficus Herba

and liquid chromatography-quadrupole-time of flight mass spectrometry (LC-Q-TOF-MS) method was used to identify the main chromatographic peaks of the fingerprints. The analysis was performed on Acquity UPLC HSS T3C18column (2.1 mm×100 mm

1.7 μm)

with gradient elution of methanol(A)-0.05% formic acid(B) at the flow rate of 0.2 mL·min-1 and the column temperature was 25℃. Part of the marked chromatographic peaks were identified. Result: HPLC fingerprints of the dry extracts of Ficus Herba were established

and the chemical constituents were identified by LC-Q-TOF-MS. 14 compounds were identified in this method. Conclusion: The established fingerprint method is suitable to the extracts of Ficus Herba and Keteling capsules

with accurate identification of the chemical compositions;it has improved the HPLC fingerprints

and provides a basis for the overall quality control of dry extracts of Ficus Herba and its prescriptions.