Objective: To study the accompanied hepatotoxicity effect of Leigongteng tablet under anti-inflammation dose

and provide theory basis for 'disease-efficacy-toxicity' correlation research. Method: The 80 male KM mice were randomly divided into 8 groups

in each group

including normal group

model group

5 Leigongteng tablet groups (51.48

36.55

25.74

18.28

12.87 μg·kg-1) and cyclophosphamide group (73 mg·kg-1). All other groups except normal group received 1% 2

4-dinitrofluorob-enzene(DNFB) solution to establish delayed type hypersensitivity models. Leigongteng tablets of different doses were given to observe the ear swelling degree and the inhibition ratio. The levels of prostaglandin E2(PGE2)

tumour necrosis factor α (TNF-α)

interleukin-2(IL-2)

alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

prealbumin(PA)

total bile acid(TBA)

total bilirubin (TBIL) in serum were detected while the ratios of organs to body weight were measured. Result: Compared with the normal group

the mice in model group had ear swelling

and the levels of PGE2

TNF-α

IL-2 and PA in serum were significantly increased (P<0.01). Compared with the model group

Leigongteng tablet could significant inhibit ear swelling and the levels of PGE2

TNF-α

and IL-2 were decreased in a dose dependent manner;the activities of serum ALT

AST

TBA and TBIL were increased;PA content was decreased;and the ratio of liver to body was increased. Conclusion: Leigongteng tablet has strong anti-inflammatory effects under the dose of 14.58 μg·kg-1 (7.01-19.06 μg·kg-1). The mechanism is related to the generation and decrease of inflammatory medium release. Toxicity and side effects of different degree can be caused to liver by administration of Leigongteng tablet at the same dosage.