Kangmin Zhike Mixture by Oral Taking or Aerosol Inhalation on Children with Cough Variant Asthma

YANG Yu; CHEN Yu-wen; CHEN Miao-ping; WANG Shi-qun; WANG Yun-yuan

doi:10.13422/j.cnki.syfjx.2016030170

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Kangmin Zhike Mixture by Oral Taking or Aerosol Inhalation on Children with Cough Variant Asthma

更新时间：2024-01-04

- Kangmin Zhike Mixture by Oral Taking or Aerosol Inhalation on Children with Cough Variant Asthma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 3, Pages: 170-173(2016)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016030170
  CLC： R725.6
- Published：2016
- 稿件说明：
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YANG Yu, CHEN Yu-wen, CHEN Miao-ping, et al. Kangmin Zhike Mixture by Oral Taking or Aerosol Inhalation on Children with Cough Variant Asthma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(3): 170-173.
DOI：

YANG Yu, CHEN Yu-wen, CHEN Miao-ping, et al. Kangmin Zhike Mixture by Oral Taking or Aerosol Inhalation on Children with Cough Variant Asthma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(3): 170-173. DOI： 10.13422/j.cnki.syfjx.2016030170.

摘要

目的:探讨抗敏止咳合剂口服/雾化吸入治疗儿童咳嗽变异性哮喘(CVA)的临床疗效及对生活质量的影响。方法:将87例患儿随机按数字表法分为对照组42和观察组45例。对照组采用孟鲁司特钠咀嚼片

<6岁4 mg

>6岁5 mg

1次/d

夜间睡前服用。观察组在对照组治疗的基础上加用抗敏止咳合剂口服/雾化吸入。两组疗程均为4周。进行治疗前后咳嗽、气急、咽痒、咳痰等症状评分

进行治疗前后莱塞斯特咳嗽生命质量问卷(LCQ)评分

检测治疗前后血清总IgE和外周血嗜酸性粒细胞(EOS)水平。结果:两组患者临床疗效经Ridit分析

观察组优于对照组(P<0.05);观察组咳嗽日间症状、咳嗽夜间症状和气急评分均低于对照组(P<0.01);观察组LCQ量表3个维度评分和总分均低于对照组(P<0.01);观察组血清总IgE和EOS低于对照组(P<0.05)。结论:抗敏止咳合剂口服和雾化吸入治疗CVA能减轻气道炎症的反应

改善咳嗽症状

以提高患儿的生活质量。

Abstract

Objective: To discuss the clinical effect of Kangmin Zhike mixture by oral taking or aerosol inhalation in treating children with cough variant asthma (CVA) and its influence to quality of life. Method: Eighty seven patients were randomly divided into control group (42 cases) and observation group (45 cases) by random number table. Patients in control group received montelukast sodium chewable tablets before sleeping at night

4 mg for children who were less than 6 years old and 5 mg for children who were more than 6 years old

1 time/day. Based on the treatment of control group

patients in observation group received additional Kangmin Zhike mixture by oral taking or aerosol inhalation. The treatment course was 4 weeks in both groups. Before and after treatment

scores of cough

ecphysesis

throat itching

expectoration and other symptoms were graded.Leicester cough questionnaire (LCQ) was made. And levels of the total IgE and peripheral blood eosinophils (EOS) in serum were detected. Result: Ridit analysis showed that

the clinical effect in observation group was superior to that in control group (P<0.05). Scores of nighttime cough

daytime cough and ecphysesis in observation groups were less than those in control group (P<0.01). Three dimension scores and total scores for LCQ in observation group were less than those in control group (P<0.01). Levels of the total IgE and EOS in serum were lower than those in control group (P<0.05). Conclusion: Kangmin Zhike mixture by oral taking and aerosol inhalation in the treatment of CVA can relieve inflammatory response in airway

ameliorate cough

and improve quality of life for patients

with significant clinical effect.

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