Objective: To observe the clinical effect of Xuebijing injection on elderly patients with chronic obstructive pulmonary disease(COPD) in acute exacerbation. Method: The 82 cases of elderly patients with COPD in acute exacerbation were randomly divided into two groups. Based on symptomatic and supportive treatments

the patients in control group were treated with 1.5 g cefoperazone sodium and sulbactam sodium which was diluted by 100 mL 5% glucose injection for intravenous drip

bid. Based on the treatment of control group

the patients in observation group also received 50 mL Xuebijing injection plus 100 mL normal saline

injection

by intravenous drip

bid. The treatment course was 14 days for both groups. The disease severity score

pulmonary function and the level of inflammatory factor before and after treatment were compared between two groups. Result: Compared with the control group

the total disease severity scores

level of forced expiratory volume in first second (FEV1)

FEV1/forced vital capacity (FVC)

C-reactive protein (CRP) and calcitonin (PCT) of the observation group were obviously improved after the treatment (P<0.05). The effective rate of the treatment group was 90.24%

higher than 80.49% in control group (P<0.05). Conclusion: For elderly patients with chronic obstructive pulmonary disease in acute exacerbation

Xuebijing injection can significantly improve clinical symptoms

signs and the level of pulmonary function

reduce inflammatory reaction

and improve the clinical efficacy.