YANG Hui-jun, PENG Jiang-yun, CHEN Yan-lin, et al. Review on Pharmacological Activities of Natural Products Against Acute Gouty Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(3): 225-230.
DOI:
YANG Hui-jun, PENG Jiang-yun, CHEN Yan-lin, et al. Review on Pharmacological Activities of Natural Products Against Acute Gouty Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(3): 225-230. DOI: 10.13422/j.cnki.syfjx.2016030225.
Review on Pharmacological Activities of Natural Products Against Acute Gouty Arthritis
Acute gouty arthritis (AGA) is a crystal joint disease caused by uric acid crystal deposition in the joints which was caused by purine metabolic disorder. By reviewing the literature reports in recent years on pharmacological effects and mechanism of natural products and their effective components against AGA
and focusing on the pathogenesis of urate crystal-induced acute gouty arthritis in animal models
we collected
summarized and analyzed the literature on targets and pharmacological action mechanism of natural products and their effective components against acute gouty arthritis. Studies have shown that the main effective components in natural products against acute gouty arthritisinclude flavonoids
alkaloids
polyphenols
saponins
and coumarin
etc. They fight against the acute gouty arthritis through anti-inflammatory
analgesic and inhibiting the release of inflammatory mediators as well as its related signaling pathways
antioxidant mechanism and multiple drug targets. Targets for the treatment of acute gouty arthritis are single in western medicine
with more serious side effects
thus not conducive to control the recurrence of acute gouty arthritis. Natural products in traditional Chinese medicines have a thousand years of history and experience in prevention and treatment of acute gouty arthritis. Compared with the western medicine
natural medicine has shown great potential and advantages of multiple targets and few side effects for the acute gouty arthritis. In recent years
more and more researchers use experimental pharmacology and molecular biology method to study the effect of natural products and their effective components against acute gouty arthritis
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Related Author
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Related Institution
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The First Affiliated Hospital of Henan University of Chinese Medicine
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