Investigation of Quantitative Analysis Method of Ferulic Acid from Awei Haipiaoxiao Soft Capsules

WANG Juan; MA Gui-zhi; GAO Juan; LI Si-yuan; YU Fu-sheng; WANG Chang-hong; TENG Liang

doi:10.13422/j.cnki.syfjx.2016040024

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Investigation of Quantitative Analysis Method of Ferulic Acid from Awei Haipiaoxiao Soft Capsules

更新时间：2024-01-04

- Investigation of Quantitative Analysis Method of Ferulic Acid from Awei Haipiaoxiao Soft Capsules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 4, Pages: 24-28(2016)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016040024
  CLC： R286.0
- Published：2016
- 稿件说明：
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WANG Juan, MA Gui-zhi, GAO Juan, et al. Investigation of Quantitative Analysis Method of Ferulic Acid from Awei Haipiaoxiao Soft Capsules[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(4): 24-28.
DOI：

WANG Juan, MA Gui-zhi, GAO Juan, et al. Investigation of Quantitative Analysis Method of Ferulic Acid from Awei Haipiaoxiao Soft Capsules[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(4): 24-28. DOI： 10.13422/j.cnki.syfjx.2016040024.

摘要

目的: 建立阿魏海螵蛸软胶囊中阿魏酸的定量分析方法

为该制剂的质量控制提供参考。方法: 以甲醇体积分数、溶剂用量、超声时间为自变量

阿魏酸峰面积为因变量

利用响应面设计优选阿魏海螵蛸软胶囊中阿魏酸的超声提取工艺。采用HPLC测定阿魏海螵蛸软胶囊中阿魏酸的含量

流动相乙腈-0.1%磷酸溶液(15 :85)

检测波长322 nm。结果: 阿魏海螵蛸软胶囊中阿魏酸的最佳超声提取工艺为以79%甲醇为提取溶媒

溶剂用量4.2倍/粒

超声时间33 min。阿魏酸质量0.919 2 μg/粒。结论: 该方法简便、准确、重复性好

可用于阿魏海螵蛸软胶囊的质量控制。

Abstract

Objective: To establish a quantitative analysis method for ferulic acid from Awei Haipiaoxiao soft capsules

which laid a test base for quality control of this preparation. Method: Independent variables were methanol concentration

solvent amounts and extracting time

dependent variable was peak area of ferulic acid

response surface methodology was adopted to optimize ultrasonic-assisted extraction technology

and an HPLC method for determining the content of ferulic acid from Awei Haipiaoxiao soft capsules was established. Result: Optimum extraction process was as following:adding 4.2 times the amount of 79% methanol

extraction time of 33 min.Conditions of HPLC were as follows:mobile phase of acetonitrile-0.1% phosphoric acid solution (15 : 85)

flow rate of 1.0 mL · min-1

detection wavelength at 322 nm.The content of ferulic acid was 0.919 2 μg per grain. Conclusion: This quantitative analysis method of ferulic acid from Awei Haipiaoxiao soft capsules is simple

accurate and reproducible

which can be used for quality control of this preparation.

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Related Institution

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