Objective: To discuss the effect of on outcomes of precancerous lesions of gastric cancer (PLGC) in patients with chronic atrophic gastritis(CAG) (qi-stagnation syndrome of liver and stomach)

as well as on serum trilobites factor 3 (TFF3) and gastric secrete element-17. Method: Eighty-nine PLGC patients were randomly divided into control group (44 cases) and observation group (45 cases) based on the principles of digital meter method to 1 : 1. Patients in control group orally took Weisu granules

15 g/time

3 times/day. Patients in observation group orally took Shenzhi Xiaowei decoction

1 dose/day. Treatment course was 16 weeks for both groups. Histopathological examination was done for gastric mucosa before and after treatment. Gastric cavity pain

fullness

distension

belching and anorexia were scored before and after treatment. TFF3 and gastric secrete element-17 levels were detected before and after treatment. Result: Total effective rate for gastroscope and gastric mucosa clinical pathological effect was 100% in both group

superior to 84.1% in control group (P<0.05). The pathology scores of atrophy degree

intestinal metaplasia (IM) and dysplasia (Dys) in observation group were lower than those in control group(P<0.01). The scores of gastric cavity pain

fullness

distension

belching and anorexia in observation group were lower than those in control group (P<0.01). Serum TFF3 in both group went down obviously after treatment

while the declined degree in observation group was more significant (P<0.01). Serum gastric secrete element-17 level in both group went up obviously after treatment

while the increase degree in observation group was more significant (P<0.01). Conclusion: Shenzhi Xiaowei decoction can block or reverse the precancerous lesions of gastric cancer (PLGC)

and delay the development of CAG to gastric cancer

with significant clinical effect.