Objective: To evaluate the efficacy and safety of Yadanzi oil grease injection combined with chemotherapy in patients with gastric cancer. Method: Databases such as Pubmed

Embase

Medline

Cochrane Library

CNKI

Wanfang

VIP and CBM were searched for qualified randomized controlled trials (RCTs). Cochrane system evaluation method was used for the methodological quality assessment of included randomized controlled trials (RCTs)

and Revman 5.2 software was used for analysis. Result: 9 RCTs involving 594 patients were included. The results of Meta analysis showed that in comparison with chemotherapy alone

the Yadanzi oil grease injection combined with chemotherapy could more significantly increase partial remission rate[OR=1.74

95%CI(1.23

2.47)

P=0.002]

overall remission rate[OR=2.45

95%CI (1.71-3.51)

P<0.000 01]and could significantly improve the quality of life for patients (KPS score>10)[OR=2.73

95%CI (1.25

5.96)

P=0.01]. In respect of chemotherapy adverse events

the risks of hand-foot syndrome

nausea and vomiting

diarrhea

leukopenia

thrombocytopenia

and neutropenia in the combinational therapy group were lower than those in chemotherapy alone group(P<0.05). Conclusion: The existing studies showed that compared with chemotherapy alone

Yadanzi oil grease injection combined with chemotherapy can more effectively improve partial remission rate

overall remission rate and quality of life

and the incidence of chemotherapy adverse events was lower in the combinational therapy group. For the quality restriction and possible publication bias of the included studies

more high quality and large sample RCTs are needed to verify the validity.