Objective: To evaluate clinical efficacy of Liuwei Dihuang prescription in treatment of menopausal syndrome. Method: Searched WHOICTRP

The Cochrane Library

PubMed

VIP

Wanfang Data

CBM and CNKI on computer

randomized controlled trials of Liuwei Dihuang prescription in treatment of menopausal syndrome were collected

retrieval from inception to January 30

2015.Two reviewers screened literature according to inclusion and exclusion criteria

extracted data

and assessed methodological quality of these included studies.Meta-analysis was performed by RevMan 5.2 software. Result: A total of 18 randomized controlled trials involving 1 981 patients were included.Meta-analysis showed thatin treatment of climacteric syndrome either alone or in combination with other Chinese patent medicinesof Liuwei Dihuang prescription

the total clinical efficacy was superior to western medicines or other Chinese patent medicines.In the recovery rate

Liuwei Dihuang prescription was better than taking other Chinese patent medicines in treatment of climacteric syndrome

but its medication alone or combined with other Chinese patent medicines did not show better than western medicines.In terms of reducing follicle-stimulating hormone (FSH)

Liuwei Dihuang prescription alone or combined with other drugs were better than western medicines or other Chinese patent medicines

single use of Liuwei Dihuang prescription or combination therapy in reducing luteinizing hormone (LH) had no better than western medicines.Single use of Liuwei Dihuang prescription or combination therapy in elevation ofestradiol (E2) single were better than western medicines or other Chinese patent medicines

in term of reducing Kupperman score

Liuwei Dihuang prescription had no better than other Chinese patent medicines. Conclusion: Single use of Liuwei Dihuang prescription or combined with other Chinese patent medicines in treatment of climacteric syndrome is better than other Chinese patent medicines and western medicines without obvious adverse reactions reported in literature

because quality of literature is not high

it still needs to support a large sample randomized double-blind test theory.