Objective: To compare contents of alkaloids between Coptidis Rhizoma

bile processed products of Coptidis Rhizoma and their water decoctions

dissolution of alkaloids in Coptidis Rhizoma was determined after being processed with pig's bile.Aim of this study was to explore processing mechanism of cold property enhancement of bile processed products. Method: Total alkaloids in Coptidis Rhizoma

bile processed products and their water decoctions were determined by UV.Contents of berberine

jatrorrhizine and palmatine in Coptidis Rhizoma

bile processed products and their water decoctions were determined by HPLC

mobile phase was acetonitrile-phosphate triethylamine solution by gradient elution at room temperature

detection wavelength was set at 345 nm. Result: Transfer rates of total alkaloids from water decoctions of Coptidis Rhizoma and its bile processed products were 71.17% and 78.50%;transfer rates of jatrorrhizine

palmatine and berberine in water decoction of Coptidis Rhizoma were 73.93%

51.59% and 56.16%;transfer rates of jatrorrhizine

palmatine and berberine in water decoction of bile processed products of Coptidis Rhizoma were 80.42%

64.21% and 64.79%

respectively. Conclusion: Being processed with pig's bile can raise transfer rate of total alkaloids in water decoction of Coptidis Rhizoma

and then to achieve purpose of cold property enhancement of bile processed products of Coptidis Rhizoma.