CUI Yuan-yuan, XIONG Rui, CHEN Zhi-min, et al. Optimization of Molding Materials for Tiaowei Chengqi Granules[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(5): 22-24.
DOI:
CUI Yuan-yuan, XIONG Rui, CHEN Zhi-min, et al. Optimization of Molding Materials for Tiaowei Chengqi Granules[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(5): 22-24. DOI: 10.13422/j.cnki.syfjx.2016050022.
Optimization of Molding Materials for Tiaowei Chengqi Granules
Objective: To screen optimal shaping and matching excipients of Tiaowei Chengqi granules for solving moldability
dissolvability
hygroscopicity and other issues. Method: With appearance
particle size
moisture content
dissolvability and hygroscopicity of granules as indexes
single factor tests were adopted to screen kinds
ratio and amounts of excipients
then quality verification
critical relative humidity and angle of repose were investigated. Result: Optimum molding materials was mixture of lactose and mannitol
ratio of extract-lactose-mannitol (1 : 3 : 1) for granulating
these prepared granules had uniform particle size
good properties and were not easy to moisture absorption.Critical relative humidity was 69% and angle of repose was less than 40°. Conclusion: These optimized excipients can significantly improve stability of Tiaowei Chengqi granules
and this molding process is scientific and rational.
Molding Process and Quality Control of Zhiyu Granules
Optimization of Molding Process of Tangshenning Granules with Central Composite Design-response Surface Methodology
Optimization of Discrete Element Simulation Parameter Calibration Method for Traditional Chinese Medicine Extract Powder Under Low Shear Conditions
Historical Evolution and Modern Research of Processing of Cyperi Rhizoma: A Review
Related Author
MU Hong
LIU Shu-min
YANG Bu-ke
ZHANG Chong
FAN Zhen-qun
FANG Yuan
LI Ting
YE Dou-dan
Related Institution
Jiangsu Kanion Pharmaceutical Co. Ltd.
State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,Nanjing University of Chinese Medicine
Beijing Key Laboratory for Production Process Control and Quality Evaluation of Chinese Medicine,Beijing University of Chinese Medicine
School of Pharmacy, Shandong University of Traditional Chinese Medicine (TCM)