Objective: To set up the multi-wavelength fusion UPLC fingerprint of 10 batches of Chuanxiong Rhizoma from different regions

initially identify common peaks

and compare the Chuanxiong Rhizoma from different regions through fingerprints

and provide the basis for its quality control and medicinal material identification. Method: UPLC was used to set up the multi-wavelength fingerprints of Chuanxiong Rhizoma from different regions. SPSS 19.0 data statistics software was used to analyze the differences of Chuanxiong Rhizoma in different regions

and full time multiple wave length fusion technology was used for multiple wavelength fusion of dif date. Q-TOF method was used to identify the common peaks in fingerprints. Result: Fingerprints of multi-wavelength fusion of Chuanxiong Rhizoma were established;20 common peaks were determined and 8 peaks of them were identified. By clustering analysis and similarity evaluation

it was found that Yunnan Chuanxiong Rhizoma had certain difference with other regions. Conclusion: The fingerprints were reproducible and can be able to distinguish the Chuanxiong Rhizoma from different regions. This method can be applied for quality control of Chuanxiong Rhizoma.