Objective: To observe the effect of Yishen Huashi granules combined with sulodexide on oxidative stress and endothelial function in early diabetic nephropathy of elder patients. Method: The 86 patients with early diabetic nephropathy were randomly divided into control group and observation group. Both groups were given with conventional therapy. The patients in control group were also treated with sulodexide intramuscular injection 600 LSU

once daily;after continuous treatment for 2 weeks

sulodexide soft capsules were orally taken

1 capsule/time

2 times daily

and continuous for 4 months. The patients in observation group were also treated with Yishen Huashi granules based on the treatment of control group

10 g/time

3 times daily

and continuous for 4 months. Blood glucose

serum creatinine (SCr)

superoxide dismutase (SOD)

malondialdehyde (MDA)

vascular pseudo von Willebrand factor (vWF)

endothelin (ET)-1 and 24 h urinary albumin excretion rate (24 h UAER) were observed before and after treatment. Result: The levels of 24 h UAER and SCr in the two groups were significantly decreased after treatment (P<0.05

P<0.01). The levels of 24 h UAER and SCr in the observation group were (72.3±15.8) mg · (24 h)-1

and (65.8±20.6) μmol · L-1

significantly lower than (87.6±17.2) mg · (24 h)-1

(91.6±23.8) μmol · L-1 in the control group

with statistically significant difference (P<0.05). The levels of MDA

vWF

and ET-1 in the observation group were (4.01±0.4) μmol · L-1

(159.5±26.4)%

and (55.7±7.2) ng · L-1 after treatment

significantly lower than those before treatment (P<0.05) and significantly lower than (5.31±0.51) μmol · L-1

(181.3±28.2)%

and (60.4±7.5) ng ·L-1 in the control group after treatment

with statistically significant difference (P<0.05). The level of SOD in the observation group was (129.3±7.1) U · mL-1after treatment

significantly higher than the level before treatment (P<0.05) and significantly higher than (70.2±4.5) U · mL-1in the control group after treatment

with statistically significant difference (P<0.05). Conclusion: Yishen Huashi granules have strong antioxidant effect

which can effectively delay the vascular endothelial injury and reduce urinary protein excretion. Yishen Huashi granules combined with sulodexide have more obvious effect on regulating vascular endothelial function and delaying the development of early diabetic nephropathy.