Comparison Between  Dissolution of Two Kinds of Commercially Available Erzhi Wan Preparations

JIN Xiu-li; TAN Le-jun; WANG Meng

doi:10.13422/j.cnki.syfjx.2016060001

您当前的位置：

首页 >

文章列表页 >

Comparison Between Dissolution of Two Kinds of Commercially Available Erzhi Wan Preparations

更新时间：2024-01-04

- Comparison Between Dissolution of Two Kinds of Commercially Available Erzhi Wan Preparations
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 6, Pages: 1-4(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2016060001
  CLC： R283.6
- Published：2016
- 稿件说明：
移动端阅览
JIN Xiu-li, TAN Le-jun, WANG Meng. Comparison Between Dissolution of Two Kinds of Commercially Available Erzhi Wan Preparations[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(6): 1-4.
DOI：

JIN Xiu-li, TAN Le-jun, WANG Meng. Comparison Between Dissolution of Two Kinds of Commercially Available Erzhi Wan Preparations[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(6): 1-4. DOI： 10.13422/j.cnki.syfjx.2016060001.

摘要

目的: 考察二至丸水蜜丸和配方颗粒中5种药效活性成分的溶出情况

比较这些成分在2种剂型中的体外溶出特点。方法: 参照《中国药典》2010年版二部附录X C溶出度测定法

采用第二法桨法

转速75 r·min-1

测试不同溶出介质(水

30%乙醇

0.1 mol·L-1盐酸和pH 4.5

6.8的磷酸盐缓冲液)。利用UPLC测定2种剂型中红景天苷、特女贞苷、女贞苷、木犀草素和齐墩果酸5种药效成分的体外溶出度

比较2种制剂的溶出行为。结果: 在各个溶出介质中

二至丸2种不同制剂中各活性成分的溶出行为差别很大

配方颗粒中红景天苷、特女贞苷、女贞苷在各个介质里都能快速溶出且溶出量高(>85%);而水蜜丸中木犀草素和齐墩果酸只能在pH 6.8 磷酸盐缓冲液中溶出很少的量(<30%)。从差异因子和相似因子分析

2种制剂中相同成分的溶出曲线无相似性。结论: 和水蜜丸相比

配方颗粒中活性成分的累积溶出量更高

且在同一种溶出介质中

能溶出更多的药效成分。说明在体外溶出方面

配方颗粒这种新型的中药形式具有更大的优势。建立的溶出度方法可以应用于二至丸制剂的质量控制。

Abstract

Objective: To investigate in vitro dissolution of five active ingredients in water-honeyed pills and dispensing granules of Erzhi Wan

and to compare dissolution behavior of five ingredients in these two preparations. Method: In vitro dissolution of Erzhi Wan was studied in formulations of water-honeyed pills and dispensing granules in different media (water

30% ethanol

0.1 mol·L-1 HCl

PBS with pH of 4.5 and 6.8) by following the 2010 edition of Chinese Pharmacopoeia through the second method (the paddle method)

rotation speed was set 75 r·min-1.UPLC was developed and validated to detect simultaneously in vitro dissolution of five active ingredients (salidroside

specnuezhenide

nuezhenoside

luteolin

oleanolic acid).Different parameters were employed to evaluate dissolution characteristics of these two preparations. Result: In different dissolution media

dissolution behavior of five ingredients in these two preparations had great difference.Salidroside

specnuezhenide and nuezhenoside in dispensing granules could dissolve fast and had high dissolution percentages (>85%) in each medium.Luteolin and oleanolic acid in water-honeyed pills dissolved very little (<30%) only in PBS with pH 6.8.Form difference factor of f1 and similarity factor of f2

the same ingredient in these two preparations had different dissolution behavior. Conclusion: Compared with water-honeyed pills

active ingredients in dispensing granules have a higher cumulative dissolution

and in the same medium

medicinal ingredient can be dissolved more.Dispensing granules has great advantage in the aspect of in vitro dissolution.This developed method can be applied for quality control of Erzhi Wan preparations.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Comparison of Zhuyao and Douchi Ligustri Lucidi Fructus Based on Quality Investigation of Commercial Samples

Investigation of Factors Influencing on Extraction Efficiency of Active Constituents in Ligustri Lucidi Fructus and Optimization of Ethanol Extraction Process of Zhenzhi Granules

Quality Correlation Analysis Among Raw Herbs,Decoction Pieces,Extract and Dispensing Granules of Chaenomelis Fructus from Xuancheng City

Analysis on Quality Standard of Hedyotis Herba Dispensing Granules Based on Standard Decoction

Analysis on Quality Standard of Sennae Folium（Cassia angustifolia） Dispensing Granules Based on Standard Decoctions

Related Author

Qi LU

Juanjuan ZHU

Zhan LIU

Benzheng SU

Yanpeng DAI

Dianhua SHI

Jun ZHANG

WANG Ying

Related Institution

Occupational Diseases Hospital of Shandong First Medical University

Shandong Academy of Chinese Medicine

Shandong Institute for Food and Drug Control

Shandong Provincial Traditional Chinese Medicine Technology Innovation Center for Treatment of Respiratory Diseases，Shandong Hongjitang Pharmaceutical Group Co. Ltd.

Shandong Technical Innovation Center for Traditional Chinese Medicine Treatment of Respiratory Diseases，Shandong Hongjitang Pharmaceutical Group Co. Ltd.

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰