TANG Tao, ZANG Qiao-zhen, LONG Kai-hua, et al. Preparation and Release Properties of Paeonol-loaded PEG-PLGA Nanoparticles Modified by Chitosan[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(6): 8-11.
DOI:
TANG Tao, ZANG Qiao-zhen, LONG Kai-hua, et al. Preparation and Release Properties of Paeonol-loaded PEG-PLGA Nanoparticles Modified by Chitosan[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(6): 8-11. DOI: 10.13422/j.cnki.syfjx.2016060008.
Preparation and Release Properties of Paeonol-loaded PEG-PLGA Nanoparticles Modified by Chitosan
Objective: To prepare paeonol-loaded polyethylene glycol (PEG)-poly(lactic-co-glycolic acid) (PLGA) nanoparticles modified by chitosan and investigate its in vitro release behavior. Method: Taking PEG-PLGA as carrier material
chitosan as surface modifier
paeonol-loaded PEG-PLGA nanoparticles modified by chitosan was prepared by nano precipitation method
formulation of this preparation was optimized by orthogonal design
characteristics of nanoparticles were evaluated.In vitro release of this preparation was characterized with phosphate buffer (pH 7.4) as medium. Result: After being modified by chitosan
particle size of paeonol-loaded PEG-PLGA nanoparticles increased
while its Zeta potential turned to positive charge
its shape was spherical.Mean particle size
Zeta potential
drug loading efficiency and encapsulation efficiency were (96.6±3.2) nm
(30.61±0.34) mV
10.87% and 79.37%.Accumulated release rate of this nanoparticles reached 62.4% at 24 h. Conclusion: Paeonol-loaded PEG-PLGA nanoparticles modified by chitosan is prepared successfully
which shows a sustained-release characteristics with good in vitro properties.