Objective: To observe the protective effects of Shenlou Shuangxin(SLSX) pills on the myocardial ischemia reperfusion injury in rats. Method: Totally 80 male Wistar rats were randomly divided into sham operation group

model group

diltiazem group

danlou tablets group

and SLSX pills (0.35

0.7

1.4

2.8 g·kg-1) groups. The model was induced by threading the left anterior descending coronary artery in each group

instantly giving the drugs

10 min later ligating the left anterior for 45 min

and reperfusing for 180 min. Sham operation group was only threaded

but not ligated. After the modeling

efforts were made to observe the changes in myocardial infarct range

serum creatine kinase (CK)

creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH). Result: Compared with sham operation group

model group showed significant increases in CK

CK-MB

LDH and myocardial infarct range (P<0.01); Compared with the model group

all SLSX pills groups had significant differences in myocardial infarct range

except for SLSX pills 0.7 g·kg-1 group (P< 0.05

P<0.01); Compared with the model group

all SLSX pills groups showed obvious declines in serum CK

LDH and CK-MB

except for SLSX pills 2.8 g·kg-1 group (P<0.05

P<0.01). Conclusion: SLSX pills has the protective effect on myocardial ischemia reperfusion injury in rats by reducing the myocardial infarct area and the level of serum myocardial enzyme.