Objective: To observe effect of postpartum depression on offspring by taking postpartum depression offspring animal model

and to identify treatment of Yueju Ganmai Dazao decoction can improve depressive behavior of postpartum depression offspring. Method: Afetr animal model of postpartum depression was successfully established

Balb/c male offspring mice were divided as normal group (CTL-F1

n=16)

postpartum depression offspring group (PPD-F1

n=8)

postpartum depression offspring treated with saline (Veh

n=8) and postpartum depression offspring treated with Yueju Ganmai Dazao decoction (YG

n=8).Veh treated with normal saline by 10 mL·kg-1

YG given Yueju Ganmai Dazao decoction with 8.3 g·kg-1

tail suspension test and novelty suppressed-feeding test were used to observe depressive behavior of mice. Result: Immobility time of PPD-F1 was significantly longer than that of CTL-F1 in tail suspension test

food intake significantly decreased in novelty suppressed-feeding test.However

compared with Veh

immobility time of YG significantly shortened and its food intake significantly increase. Conclusion: Postpartum depression offspring more easily shows depressive behavior

Yueju Ganmai Dazao decoction can quickly and effectively improve this depressive behavior.