Objective: To investigate the clinical efficacy of Modified Chishizhi Yuyuliang Tang for cirrhosis ascites of spleen-kidney-yang deficiency and its effect on glucose (GLU) and lactate dehydrogenase (LDH) levels in ascitic fluid and serum-ascites albumin gradient (SAAG). Method: One hundred and four patients with cirrhosis ascites of spleen-kidney-yang deficiency were randomly divided into control group (52 cases) and treatment group (52 cases) with digital table method. By referring to the treatment methods in 'A Consensus Opinion on The Diagnosis and Treatment of Cirrhosis Ascites in The Traditional Chinese and Western Medicine'

patients of both groups were treated with therapy of sodium restriction

liver protection and diuresis. Patients of control group were treated with entecavir tablets (0.5 mg/time

qd) by orally taking. Patients of treatment group were also treated with Modified Chishizhi Yuyuliang Tang based on the treatment in control group (1 dose/d in form of water decoction

bid). The treatment course was 4 weeks for both groups. The traditional Chinese medicine (TCM) symptom scores in both groups were compared before and after treatment.The width of the trunk of vena portae and vena lienalis and the depth of ascites were detected by B ultrasound. LDH and GLU levels in ascites were detected for both groups. Levels of SAAG were compared in two groups before and after treatment. Result: The TCM symptom scores in treatment group were significantly lower than those in control group after treatment (P<0.01). The total efficacy of treatment group was 88.46%

significantly higher than 67.31% in control group

with statistically significant difference (P<0.05). Compared with control group

the width of the trunk of vena portae and vena lienalis and the depth of ascites were significantly lower in treatment group after treatment (P<0.05

P<0.01). Levels of LDH

GLU in ascites and SAAG were significantly lower in the treatment group than those in control group after treatment

with statistically significant differences (P<0.01). Conclusion: Modified Chishizhi Yuyuliang Tang combined with entecavir for cirrhosis ascites of spleen-kidney-yang deficiency could evidently improve the TCM symptoms

cirrhotic portal hypertension

clinical therapeutic effects of ascitic fluid and reduce levels of LDH

GLU in ascites and SAAG level.