Objective: To evaluate the clinical efficacy and safety of Shenkang pills in treating Qi deficiency and blood stasis combining with dampness accumulation refractory nephritic syndrome (RNS). Method: Sixty patients of RNS with Qi deficiency and blood stasis combining with dampness accumulation

were randomly divided into two groups. 30 cases in the control group only received Western medicine treatment

and 30 cases in the treatment group were also treated with Shenkang pills based on Western medicine treatment. Patients in both groups were treated continuously for 3 months. The clinical effects were observed

including plasma albumin (Alb)

24 hours urine protein quantity(24 h Upr)

blood lipids [total cholesterol (TC)

triglyceride (TG)]

coagulation/fibrinolysis [fibrinogen (Fg)

D-dimer (D-D)

thrombin time (TT)

kaolin partial thromboplastin time (APTT)] and traditional Chinese medicine (TCM) syndrome. Result: There was significant difference in 24 h Upr in treatment group before and after the treatment (P<0.01)

and there was significant difference between the two groups after treatment (P<0.01). There was significant difference in TC

Alb and TG in treatment group before and after the treatment (P<0.01).TC and Alb of the control group were statistically significant before and after treatment (P<0.05)

but TG had no statistical significance

and there was significant difference (P<0.01) between the two groups after treatment. There was significant difference in Fg

D-D

APTT and TT in treatment group before and after treatment (P<0.01);Fg

D-D and APTT of control group after treatment were statistically significant (P<0.05)

while change of TT had no statistical significance

and there was statistical significant difference between the two groups after treatment (P<0.05). There was statistically significant difference in efficacy of traditional Chinese medicine(TCM) syndrom between two groups after treatment (P<0.01). Conclusion: Shenkang pills combined with western medicine therapy can significantly reduce 24 h Upr

elevate Alb

improve the symptoms of TCM syndrom and state of high coagulation

decrease blood fat

and significantly reduce and relieve the adverse reaction of the hormone and immune inhibitors.