Objective: To observe the effect of Xuanfu Daizhe Tang combined with point-injection on chemotherapy-induced nausea and vomiting (CINV). Method: Totally 72 patients with chemotherapy for malignant tumors were randomly divided into control group and treatment group. The patients in control group were intravenously injected with ondansetron hydrochloride injection (8 mg/time

bid). Patients in treatment group also received Xuanfu Daizhe Tang by orally taking on the basis of treatment in control group

1 dose/d and point-injection with Huangqi injection (4 mL/time

bid). The effective control rate for vomiting

appetite

Karnofsky(KPS) score changes

body weight changes

blood indicator changes and adverse event incidence were observed and compared. Result: The effective control rate for vomiting was 72.2% and 83.3% in acute phase respectively for the control group and treatment group;while in the delayed phase

the effective control rate for vomiting was 61.1% and 75.0% respectively;the effective control rates in treatment group were higher than those in control group in both phases

with statistically significant difference between two groups (P<0.05). The increases in appetite and KPS scores in the treatment group were also higher than those in the control group

with statistically significant difference between two groups (P<0.05). After chemotherapy

the body weight changes in treatment group were lower than those in control group

with statistically significant difference between two groups (P<0.05). After chemotherapy

leukocytes

platelet levels and hemoglobin concentration in the treatment group were higher than those in control group

with statistically significant difference between two groups (P<0.05). The incidence of adverse events in the treatment group was all lower than that in the control group

with statistically significant difference between two groups (P<0.05). Conclusion: Xuanfu Daizhe Tang combined with point-injection of Huangqi injection has clear curative effect in the treatment of CINV. It could improve the physical conditions and appetite of patients

and reduce the incidence of adverse events. Therefore

it is worth to be widely used clinically.