LIN Wei-dong, MA Wen-yuan, TIAN Yuan-xin, et al. Investigate Material Foundation of Puerariae Radix for Improving Insulin Resistance Based on Molecular Docking Technology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(6): 194-199.
DOI:
LIN Wei-dong, MA Wen-yuan, TIAN Yuan-xin, et al. Investigate Material Foundation of Puerariae Radix for Improving Insulin Resistance Based on Molecular Docking Technology[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(6): 194-199. DOI: 10.13422/j.cnki.syfjx.2016060194.
Investigate Material Foundation of Puerariae Radix for Improving Insulin Resistance Based on Molecular Docking Technology
Objective: To predict the possible active ingredients of Puerariae Radix in improving insulin resistance based on molecular docking technology. Method: The 19 key targets related with insulin resistance were selected
and drug-likeness analysis and molecular docking technology were used to virtually screen 63 compounds of Puerariae Radix. Meanwhile
drug-target network models were established by software Cytoscape 3.2.1 for network analysis. Result: The 19 components in radix puerariae higher than the target ligand and with the drug-like ingredients were screened
indicating these molecules were possibly the main active components of radix puerariae in improving insulin resistance. It preliminarily revealed the material foundation of Puerariae Radix in improving insulin resistance. Conclusion: The present approach is helpful to find the active components of Puerariae Radix in improving insulin resistance.
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