Research Progress on Toxicity of Alkaloids in Sophorae Tonkinensis Radix et Rhizoma

TIAN Xue-song

doi:10.13422/j.cnki.syfjx.2016060230

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Research Progress on Toxicity of Alkaloids in Sophorae Tonkinensis Radix et Rhizoma

更新时间：2024-01-04

- Research Progress on Toxicity of Alkaloids in Sophorae Tonkinensis Radix et Rhizoma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 22, Issue 6, Pages: 230-234(2016)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2016060230
  CLC： R285.1
- Published：2016
- 稿件说明：
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TIAN Xue-song. Research Progress on Toxicity of Alkaloids in Sophorae Tonkinensis Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(6): 230-234.
DOI：

TIAN Xue-song. Research Progress on Toxicity of Alkaloids in Sophorae Tonkinensis Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(6): 230-234. DOI： 10.13422/j.cnki.syfjx.2016060230.

摘要

目的: 介绍山豆根中生物碱的毒性研究进展。方法: 查阅国内外相关资料从临床表现、实验室研究及毒性机制3个方面

对山豆根毒性研究进行汇总、分析、综述。结果: 山豆根具有神经毒性、肝毒性、心血管毒性及引起胃肠道反应、过敏反应。毒性以胃肠道反应、肝毒性为主

但是以神经毒性为最。结论: 山豆根中生物碱是引起毒性反应的物质基础

其中苦参碱和氧化苦参碱是主要毒性成分

超剂量服用是中毒的主要原因

毒性机制与抑制体内乙酰胆碱酯酶活性及氧化应激、炎症损伤相关。

Abstract

Objective: To introduce the research progress on toxicology of alkaloids in Sophorae Tonkinensis Radix et Rhizoma(STRR). Method: The studies on toxicity of STRR were summarized

analyzed and reviewed from clinical manifestations

laboratory studies and toxicity mechanism by accessing relevant information and references. Result: STRR has neurotoxicity

hepatotoxicity

cardiovascular toxicity

and can induce gastrointestinal side effects and allergic reaction. The toxicity was focused on gastrointestinal side effects and hepatotoxicity. However

neurotoxicity was most significant. Conclusion: Alkaloids of STRR are the material basis for toxic reaction. Both matrine and oxymatrine are the major toxic components of STRR. Overdose is a major cause of poisoning and the mechanism of toxicity is primarily related to the inhibition of acetylcholinesterase activity and oxidative stress as well as inflammatory injury.

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Related Institution

School of Pharmaceutical Sciences， Changchun University of Chinese Medicine

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