Objective: To optimize water extraction process of Shenqi compound granules and investigate effects of different factor on the content of saponins in water extract and concentrated solution. Method: HPLC-ELSD was employed to determine contents of ginsenoside Rg1

ginsenoside Re

ginsenoside Rb1 and astragaloside Ⅳ at the same time.Based on single factor tests

taking solid-liquid ratio

extraction time and times as factors

orthogonal test was adopted to optimized extraction process with composite score of the content of saponins and yield of dry extract as index.Stability of Shenqi compound granules was investigated by determining the content of saponins in water extract and concentrated solution under different factor. Result: Optimum extraction process was as follows:extracted thrice with 10 times the amount of water

40 min for each time.Extracting amounts of ginsenoside Rg1

ginsenoside Re

ginsenoside Rb1 and astragaloside Ⅳ were 1.556

2.155

2.168

0.718 mg · g-1.Heating temperature and time was main factors affecting content change of saponins in Shenqi compound granules. Conclusion: High temperature and long time heating should avoid in preparation process of Shenqi compound granules

vacuum concentration method and vacuum drying method should be adopted to reduce degradation rate of ginsenosides.This optimized extraction process is feasible and suitable for industrial production of Shenqi compound granules.